摘要
目的:研究血清炎症因子水平在肺内外源性急性呼吸窘迫综合征(ARDS)中的差异。方法:选择我院ICU 2015年2月～2017年10月收治的21例ARDS患者为研究对象,按不同原发病因将所有对象分为两组:肺内源性ARDS组(ARDSp组,11例)和肺外源性ARDS组(ARDSexp组,10例)。采用流式微球技术(cytometric bead array,CBA)测定两组患者血清中6种炎症因子IL-8、IL-6、IL-1β、IL-10、IL-12p70、TNF-α的浓度,比较两组患者血清中各炎症因子水平是否存在差异。结果:两组血清中IL-6、IL-1β、IL-10、IL-12p70、TNF-α浓度比较,差异无统计学意义(P>0.05); ARDSexp组血清IL-8浓度高于ARDSp组(P<0.05)。结论:监测血清IL-8水平有助于肺外源性ARDS的诊治。
Objective:To investigate the differences of serum inflammatory cytokines in acute respiratory distress syndrome(ARDS)caused by either endogenous or exogenous pulmonary and extrapulmonary disease.Methods:Twenty-one cases of ARDS admitted to and treated in our department were included from February 2015 to October 2017,and divided into ARDSp group(n=11)and ARDSexp group(n=10)according to causes.Cytometric bead array(CBA)technique was used to determine the level of inflammatory cytokines,including IL-8,IL-6,IL-1β,IL-10,IL-12p70 and TNF-αin serum.Then the serum inflammatory cytokines were compared between groups.Results:Serum level of IL-6,IL-1β,IL-10,IL-12p70 and TNF-αwas not significantly different between the two groups(P>0.05),yet patients in ARDSexp group had higher level of IL-8 than those in ARDSp group(P<0.05).Conclusion:Determination of serum IL-8 level can contribute to diagnosis and treatment ARDS caused by exogenous pulmonary conditions.
作者
蒋金萍
张慧娟
陈群
曹迎亚
鲁卫华
JIANG Jinping;ZHANG Huijuan;CHEN Qun;CAO Yingya;LU Weihua(Department of Critical Care Medicine,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)
出处
《皖南医学院学报》
CAS
2018年第6期560-562,共3页
Journal of Wannan Medical College
基金
安徽省高校拔尖人才项目(gxbj ZD19)
安徽省学术和技术带头人后备人选科研项目(2017H145)
关键词
急性呼吸窘迫综合征
肺内源性
肺外源性
炎症因子
白介素-8
acute respiratory distress syndrome
endogenous pulmonary disease
exogenous pulmonary condition
inflammatory cytokines
IL-8
