摘要
目的研究分泌性中耳炎(OME)伴腺样体肥大(AH)患儿IL-5因子的表达水平及临床意义。方法选择2015年1月～2017年月诊治的25例OME伴AH患儿(OME伴AH组)、30例单纯OME患儿(单纯OME组)、30例单纯AH患儿(单纯H组)以及25例正常儿童(对照组)。采用酶联免疫吸附试验(ELISA)检测相关腺样体、血清白细胞介素5、6、8(IL-5、IL-6、IL-8)水平。结果 OME伴AH组腺样体IL-5、IL-6水平高于单纯AH组,差异具有统计学意义(P<0.05);OME伴AH组与单纯OME组血清IL-5、IL-6水平高于单纯OME组与对照组(P<0.05);OME伴AH组与单纯OME组、单纯OME组与对照组IL-5、IL-6水平差异无统计学意义(P>0.05);OME伴AH组、单纯OME组腺样体、血清IL-8水平差异无统计学意义(P>0.05);三组血清IL-8水平差异无统计学意义(P>0.05),但均高于对照组(P<0.05)。结论 IL-5、IL-6在OME伴AH、单纯AH患儿腺样体表达明显增高,提示其在OME的发生及发展中具有重要作用。
Objective To investigate the expression level of children's IL-5 in otitis media with effusion(OME)and adenoid hypertrophy(AH)of and its clinical significance.Methods 25 patients with OME and AH,30 children with simple OME,30 with simple AH and 25 normal children treated in our hospital from January 2015 to 2017 were selected.Enzyme linked immunosorbent assay(ELISA)was used to detect the levels of interleukin 5,6,8(IL-5,IL-6,IL-8)in the related adenoids and serum.Results The levels of IL-5 and IL-6 in adenoids of OME with AH group were significantly higher than those in AH group,the difference was statistically significant(P<0.05).The serum levels of IL-5 and IL-6 in OME with AH group and OME group were significantly higher than those in OME group and control group,the serum levels of IL-5 and IL-6 in adenoid were higher than those in serum,and the difference was statistically significant(P<0.05).There was no significant difference in the levels of IL-5 and IL-6 between the four groups(P>0.05).There was no significant difference in the levels of IL-8 in adenoid and serum between OME with AH group and OME group(P>0.05).There was no significant difference in serum IL-8 level between the three groups(P>0.05),but they were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion The expression level of IL-5 and IL-6 in adenoids of OME with AH group and AH group were significantly higher than those in serum,which suggests that they play an important role in the occurrence and development of OME.
作者
白治田
李慧
陈炜
童敏
邱昌明
BAI Zhitian;LI Hui;CHEN Wei;TONG Min;QIU Changming(Department of Otolaryngology,Yulin Second Hospital,Yulin 719000,Shanxi,China;Department of Otolaryngology,Leshan People's Hospital,Leshan 614000,Sichuan,China)
出处
《西部医学》
2018年第12期1797-1800,共4页
Medical Journal of West China
基金
四川省卫计委科研课题(17PJ188)
