摘要
目的探讨前列腺癌患者组织ERG蛋白表达与肿瘤进展的关系。方法纳入2012年3月～2016年2月前列腺穿刺证实为前列腺癌且符合主动监测条件的56名患者,收集患者年龄、血清前列腺特异性抗原(PSA)水平、格里森评分(GS)、临床分期等临床病理学参数,采用免疫组织化学的方法检测前列腺癌穿刺组织中ERG蛋白的表达。ERG蛋白表达与患者临床病理学特征之间的关系采用X^2检验,Kplan-meier生存分析模型及Cox回归模型用于分析ERG蛋白表达状态与前列腺癌进展间的关系。结果 56名患者中,48名纳入最后的研究,ERG蛋白表达阳性率37.5%(18/48)。Kplanmeier生存分析模型中,ERG蛋白阳性及阴性组中位组织学无进展生存期分别为32个月和48个月(X^2=4.476,P=0.034);中位PSA无进展生存期分别为21个月及26个月(X^2=4.272,P=0.039);在多变量分析中,穿刺组织ERG蛋白表达是前列腺癌主动监测期间进展的独立危险因素(Hr=2.024,P=0.044)。结论组织ERG蛋白的表达增加了主动监测前列腺癌进展的风险,通过对其检测和分析可以为制定个体化的主动监测方案提供参考。
Objective To investigate the relationshipbetween ERG protein expression in diagnostic specimens andpro-gression for prostate cancer during active surveillance.Methods 56 patients diagnosed prostate cancer following active surveillance during March 2012 to February 2016 were recruited into the study.Parameters such as age at diagnosis,prostate-specific antigen(PSA)level at diagnosis,Gleason score(GS),clinical stage were collected retrospectively.ERG protein expression was detected by immunohistochemistry.Relationship between ERG expression status and clinicopathological characteristics was analyzed.Kaplan-meier survival model and Cox proportional hazards regression model were used to investigate the predicative roles of ERG status and clinicopathological characteristics for progression of prostate cancer during active surveillance.Results 48 patients completed the final follow-up,and 37.5%of the patients were found ERG protein positive(18/48).Kaplan-meier survival model shown the median histological progression free survival time were 32 months and 48 months(χ^2=4.476,P=0.034).The median PSA progression free survival time were 21 months and 26 months for ERG-positive group and ERG-negative group,re-spectively(χ^2=4.272,P=0.039).ERG positive was a independent predictor for prostate cancer progression during active surveillance in Cox regression(Hr=2.024,P=0.044).Conclusion The expression of ERG protein increases the risk of prostate cancer progression during active surveillance.ERG protein status can be used to individualize active surveillance programe.
作者
周文浩
龚志勇
廖波
程树林
ZHOU Wenhao;GONG Zhiyong;LIAO Bo;CHENG Shulin(Department of Urology,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)
出处
《西部医学》
2018年第12期1825-1828,1833,共5页
Medical Journal of West China
基金
南充市应用技术研究与开发项目(16YFZJ0046)
