摘要
患者,女,76岁。全身皮下多发结节伴右下肢皮肤溃烂2个月。皮损组织病理示(腹壁肿物):非霍奇金淋巴结,B细胞型,免疫表型符合DLBCL,生发中心来源。免疫组化:CD20弥漫连片(+),CD3散在(+),CD10(+),CD21显示FDC网消失,Ki67(80%)。胸腹部增强CT示胃窦十二指肠占位性病变,胃镜检查取胃窦部病变活检示:(胃窦小弯、大弯)非霍奇金B细胞淋巴瘤,考虑DLBCL或其他高侵袭性类型;免疫组化:黏膜腺体间弥漫的淋巴样细胞浸润性生长,CD20连片阳性,Ki67(90%)。我院血液科诊断为非霍奇金淋巴瘤(弥漫大B细胞型) IV期IPI,评分5分继发皮肤受累。患者家属拒绝治疗,患者出院1周后死亡。
A 76 year-old female presented with multiple subcutaneous nodules with skin ulceration on his right lower leg for 2 months.The biopsy featrues of the lesion were accordance with non-Hodgkin's lymph nodes,B cell type,immunophenotype conforms to DLBCL,germinal center source.Immunohistochemistry showed positiveity for CD20,CD3 and CD10.80%of the cells were positive for Ki67 and FDC net disappears.Enhanced CT suggested gastric antrum duodenal space-occupying lesions.The biopsy featrues of gastric antrum lesions were accordance with non-Hodgkin B Cellular lymphoma,DLBCL or other highly invasive types.Immunohistochemistry showed positivity for CD20 and Ki67(90%).The patient was diagnosed as Non-Hodgkin's lymphoma(diffuse large B-cell type)Phase IV IPI,5 scores,involving skin.The treatment was refused by the family members and the patient died after discharged one week.
作者
杨扬
杨融辉
吴斌
苗苗
廖爱军
YANG Yang;YANG Ronghui;WU Bin;MIAO Miao;LIAO Aijun(The Fifth Affiliated Zhuhai Hospital of Zunyi Medical College,Zhuhai 519100,Guangdong,China;Department of Hematology,Shengjing Hospital,China Medical University,Shenyang 110001,Liaoning,China)
出处
《中国麻风皮肤病杂志》
2018年第11期678-680,共3页
China Journal of Leprosy and Skin Diseases
