摘要
壳聚糖是自然界中含量丰富的天然高分子正电荷惰性多糖,因与其相关支架材料具有良好的生物相容性和生物降解性而在生物医学、化工、环保等领域应用广泛。在不同条件下,壳聚糖可通过氧化还原反应、水解反应、酰化反应等与不同样品复合对壳聚糖支架材料性能进行改良,从而拓展其应用范围。该研究将壳聚糖溶液与明胶、乙二醇、环氧丙烷进行不同梯度的复合,通过测量孔隙率、吸水率、SEM分析等来评价壳聚糖组织工程支架性能改良效果。结果表明,复合后的壳聚糖支架材料孔壁上孔隙数目增多,直径减小,孔隙率显著增大,1∶5乙二醇复合壳聚糖支架孔隙率显著增大,达98. 36%;1∶5乙二醇复合壳聚糖支架吸水率显著增大,达66. 21倍。
Chitosan is a natural macromolecular positive-charge inert polysaccharide which is rich in nature,and has wide application in the fields of biomedicine,chemical industry,environmental protection and the like because the related scaffold material has good biocompatibility and biodegradability.Under different conditions,chitosan can be modified by redox reaction,hydrolysis reaction and acylation reaction with different samples to improve the properties of chitosan scaffold.In this study,chitosan solution was compounded with gelatin,ethylene glycol and propylene oxide in different gradients to evaluate the performance improvement of chitosan tissue engineering scaffold by measuring porosity,water absorption and SEM analysis.The results showed that the number of pores on the pore wall of chitosan scaffold increased,the diameter decreased,the porosity of chitosan scaffold increased significantly,and the porosity of chitosan scaffold increased significantly,reached98.36%,and the water absorption rate of chitosan composite scaffold reached66.21times with1∶5ethylene glycol.
作者
樊鹏
江雨棋
张涛
董浩戎
阳范文
朱继翔
FAN Peng;JIANG Yu-qi;ZHANG Tao;DONG Hao-rong;YANG Fan-wen;ZHU Ji-xiang(Department of Clinical Medicine,Third Hospital of Clinical Medicine,Guangzhou Medical University,Guangzhou511436,Guangdong,China;Department of Biomedical Engineering,Basic College of Guangzhou Medical University,Guangzhou511436,Guangdong,China)
出处
《合成材料老化与应用》
2018年第6期31-35,共5页
Synthetic Materials Aging and Application
基金
广州医科大学大学生科技创新项目(2016A008)
广东省科技计划项目(2017B090911012)
广州市高校创新创业教育重大项目(201709P05)
广州市属高校科研项目(1201630251)
关键词
壳聚糖
复合支架
明胶
环氧丙烷
乙二醇
chitosan
composite support
gelatin
propylene oxide
glycol
