摘要
目的探讨非糖尿病患者其铁负荷水平与非酒精性脂肪性肝病(NAFLD)的相关性。方法选取2016年1月～2017年12月广西医科大学第三附属医院(以下简称"我院")募集的不伴糖尿病的NAFLD患者152例为观察组;选取同期我院体检健康者80名为对照组。记录或检测两组一般资料、生化指标、血清铁蛋白(SF)、血清铁(SI)、血清铁调素(HEPC)水平,并通过氢质子磁共振波谱测定肝脏脂肪含量(LFC);分析铁负荷指标与其他指标的关系。结果观察组SF、SI明显高于对照组,HEPC明显低于对照组,差异有统计学意义(P <0.05)。校正年龄、性别后,SF、SI均与LFC呈正相关(r=0.461,P <0.001;r=0.275,P=0.001),HEPC与LFC呈显著负相关(r=-0.479,P <0.001)。SI升高是肝功能损伤的独立危险因素(OR=1.074,P <0.05,95%CI:1.022～1.130)。SF、SI及HEPC与NAFLD活动度积分呈弱相关(r=0.172,P=0.036;r=0.192,P=0.019;r=-0.236,P=0.004),但上述相关系数均较低,缺乏临床实际意义。结论非糖尿病患者铁负荷水平上升与LFC增加、肝功能损伤有关,但其与患者肝脏炎症程度无明显相关性。
Objective To investigate the association between iron overload and non-alcoholic fatty liver disease(NAFLD)in non-diabetic patients.Methods From January 2016 to December2017,152patients with NAFLD who were not Complicated with diabetes enrolled in the Third Affiliated Hospital of Guangxi Medical University(“our hospital”for short)were selected as the observation group.Eighty healthy subjects udertaking phylical examination in our hospital were selected as the control group.Their general data,biochemical indicators,serum ferritin(SF),serum iron(SI)and serum hepcidin(HEPC)were recorded or detected,liver fat content(LFC)was evaluated by proton magnetic resonance spectroscopy.The relationships between the indexes of iron overload and other indexes were analyzed.Results SF and SI in the observation group were significantly higher than those in the control group,and HEPC was significantly lower than that in the control group,the differences were statistically significant(P<0.05).After adjustment for age and sex,both SF and SI had linear positive correlations with LFC(r=0.461,P<0.001;r=0.275,P=0.001),and HEPC had a significant linear negative correlation with LFC(r=-0.479,P<0.001).The increase of SI was an independent risk factor for liver damage(OR=1.074,P<0.05,95%CI=1.022-1.130).SF,SI,HEPC were weakly correlated with NAFLD activity scores(r=0.172,P=0.036;r=0.192,P=0.019;r=-0.236,P=0.004),but the correlation coefficients were too low,which may lacked clinical significance.Conclusion Iron overload in non-diabetic patients is related to the increase of LFC and liver function damage,but it has no correlation with the degree of liver inflammation.
作者
吴县斌
苏东星
梁艺
庞丽兴
梁肖兰
陆才金
陈庆洲
韦羽娟
战廷正
WU Xianbin;SU Dongxing;LIANG Yi;PANG Lixing;LIANG Xiaolan;LIU Caijin;CHEN Qingzhou;WEI Yujuan;ZHANG Tingzheng(Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China;Department of Cardiovascular, the Third Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China;Department of Ultrasonography, the Third Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China;Department of Parasitology, Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530031, China)
出处
《中国医药导报》
CAS
2018年第34期97-101,共5页
China Medical Herald
基金
广西壮族自治区南宁市科学研究与技术开发计划项目(20153095)
关键词
非酒精性脂肪性肝病
铁负荷
肝功能
铁蛋白质类
Non-alcoholic fatty liver disease
Iron overload
Liver function
Iron protein
