摘要
目的探讨弥漫大B细胞淋巴瘤(DLBLC)中Ki67表达与18F-FDGPET/CTSUVmax的相关性及Ki67和SUVmax在疗效评估中的应用价值。方法回顾性分析55例初诊DLBLC患者的18F-FDG PET/CT表现,观察Ki67表达程度和病灶SUVmax之间相关性;应用18F-FDGPET/CT评估疗效,分析年龄、性别、病灶SUVmax、Ki67表达程度是否为影响化疗疗效的独立因素。结果 Ki67表达程度和病灶SUVmax呈正相关(P<0.05);而DCBCL病灶SUVmax与化疗疗效无明显相关性(P>0.05);年龄、性别、病灶SUVmax和Ki67表达程度都不能作为影响化疗疗效的独立影响因素(P>0.05)。结论18F-FDGPET/CTSUVmax可以预测DLBCL的增殖情况和侵袭性,与化疗疗效无相关性;年龄、性别、病灶SUVmax和Ki67表达,均不是影响化疗疗效的独立因素。
Objective To discuss the correlation between Ki67 expression and 18F-FDG PET/CT SUVmax in patients with diffuse large B-cell lymphoma(DLBLC)and their application in the evaluation of chemotherapy effect.Methods We retrospectively analyzed 18F-FDG PET/CT images of 55 patients initially diagnosed as DLBLC in our hospital,observed the correlation between Ki67 expression and SUVmax,evaluated the chemotherapy effect by 18F-FDG PET/CT scan,and analyzed whether age,gender,SUVmax and Ki67 expression were the independent influence factors of chemotherapy effect.Results SUVmax was positively correlated with Ki67 expression(P<0.05),but no correlation with chemotherapy effect(P>0.05);Age,gender,SUVmax and Ki67 were not independent influencing factors of chemotherapy effect(P>0.05).Conclusion 18F-FDG PET/CT SUVmax could predict the proliferation and invasion of DLBCL cells,but there is no correlation between SUVmax and chemotherapy effect.Age,gender,SUVmax and Ki67 expression are not independent influencing factors of chemotherapy effect.
作者
杨明
冯彦林
刘德军
余丰文
黄克敏
李雯
冼伟均
鲁胜男
王颖
YANG Ming;FENG Yanlin;LIU Dejun;YU Fengwen;HUANG Kemin;LI Wen;XIAN Weijun;LU Shengnan;WANG Ying(Nuclear Medicine Department,The First People's Hospital of Foshan,Foshan 528000,China)
出处
《肿瘤防治研究》
CAS
CSCD
2018年第12期1004-1008,共5页
Cancer Research on Prevention and Treatment
基金
佛山市医学类科技攻关项目(2015AB00325)
