摘要
目的评价肿瘤相关巨噬细胞(TAMs)与非小细胞肺癌(NSCLC)预后的关联,为采取早期干预措施提供依据。方法计算机检索PubMed、EMBASE、MEDLINE、CBM、万方数据库、维普数据库中自建库至2018年6月20日公开发表的TAMs与NSCLC预后关联的中英文临床研究进行Meta分析,采用纽卡斯尔-渥太华量表(NOS)评价研究质量,采用χ~2检验进行异质性检验,采用固定效应模型或随机效应模型进行汇总分析。结果检索并纳入14篇有关NSCLC患者的5年生存率与病理组织内TAMs性质关系的研究。Meta分析结果显示:总TAMs密度(OR=3. 55,95%CI 1. 62～7. 78,P=0. 002)、肿瘤细胞团内TAMs密度(OR=0. 43,95%CI 0. 19～0. 97,P=0. 04)、肿瘤基质内TAMs密度(OR=1. 82,95%CI 1. 19～2. 78,P=0. 006)、肿瘤基质内M2巨噬细胞密度(OR=2. 01,95%CI1. 17～3. 45,P=0. 01)与5年生存率相关。结论 TAMs可作为预测NSCLC患者预后的指标,对临床有重要的指导意义。
Objective To systematically assess the studies on the relation between tumor-associated macrophages(TAMs)and the prognosis of non-small cell lung cancer(NSCLC)and provide evidence for the early intervention.Methods The studies were searched in PubMed,EMBASE,MEDLINE,CBM,Wanfang and VIP database from building library to June 20 th,2018.Quality ratings were made according to the NOS score,and heterogeneity test was analyzed byχ^2 test.Pooled analysis was made by Mantel-Haenszel or DerSimonian-Laird.Results Fourteen studies were included to estimate the relationship between TAMs and 5-year survival rate of NSCLC.Meta-analysis showed that there were significantly differences between 5-year survival rate of NSCLC patients and total TAMs density(OR=3.55,95%CI 1.62-7.78,P=0.002),TAMs density in tumor islet(OR=0.43,95%CI 0.19-0.97,P=0.04),TAMs density in tumor stroma(OR=1.82,95%CI 1.19-2.78,P=0.006)and total M2 TAMs density in tumor stroma(OR=2.01,95%CI 1.17-3.45,P=0.01).Conclusion TAMs could be a predictor for the survival of NSCLC patients and extremely meaningful for the clinical practice in the future.
作者
霍雨佳
许文英
王逸豪
蔡军
HUO Yujia;XU Wenying;WANg Yihao;CAI Jun(Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Pathology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《医学综述》
2018年第24期4964-4969,共6页
Medical Recapitulate
