摘要
目的探讨骨膜蛋白和p53在口腔白斑和口腔鳞状细胞癌组织中的表达、相关性及临床意义。方法采用免疫组织化学法检测30例口腔正常黏膜、30例单纯增生白斑、38例异常增生白斑以及79例口腔鳞状细胞癌组织中骨膜蛋白和p53的表达情况,并分析表达的相关性。结果对于骨膜蛋白阳性细胞面积指数和累积光密度值,除单纯增生与正常口腔黏膜的差异无统计学意义外,其余各组间的差异均有统计学意义(P<0.05);对于p53阳性细胞面积指数和累积光密度值,除单纯增生白斑与正常口腔黏膜的差异无统计学意义外,其余各组间的差异均有统计学意义(P<0.05)。异常增生白斑和口腔鳞状细胞癌组织中骨膜蛋白与p53阳性表达呈线性正相关(P<0.05)。骨膜蛋白和p53的阳性表达与肿瘤的分化程度、肿瘤TNM分期以及有无淋巴结转移有关(P<0.05)。结论骨膜蛋白和p53可能共同参与口腔鳞状细胞癌的癌变过程,骨膜蛋白和p53与肿瘤侵袭有关。
Objective This study aimed to investigate the expression and clinical significance of periostin and p53 in oral leukoplakia and oral squamous cell carcinoma.Methods The material for immunohistochemical studies consisted of 30 cases of normal oral mucosa,30 cases of hyperplasia leukoplakia,38 cases of dysplastic leukoplakia and 79 cases of oral squamous cell carcinoma.Results The index of positive cell vessels and the value of integrated optical density of periostin and p53 between every two groups,except for oral normal mucosa and hyperplasia leukoplakia,were statistically significant(P<0.05).Periostin expression in dysplastic leukoplakia and oral squamous cell carcinoma positively correlated with that of p53.Furthermore,the expression levels of periostin and p53 were significantly related to TNM stage,tumour differentiation degree and lymph node metastasis(P<0.05).Conclusion Periostin and p53 may be involved in the carcinogenesis of oral squamous cell carcinoma and associated with tumour invasion.
作者
李群
关为群
张杨安
黄志超
Li Qun;Guan Weiqun;ZhangYang’an;Huang Zhichao(Dept. of Stomatology,Fujian Medical University Union Hospital,Fuzhou 350001,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2019年第1期5-11,共7页
International Journal of Stomatology
基金
福建省医学创新课题资助项目(2018CXB-9)~~
关键词
骨膜蛋白
P53
口腔白斑
口腔鳞状细胞癌
癌变
periostin
p53
oral leukoplakia
oral squamous cell carcinoma
carcinogenesis
