摘要
目的:比较Deauville 5分法及△SUV法在化疗中期滤泡性淋巴瘤(follicular lymphoma,FL)患者预后评估中的作用。方法:回顾性分析2009年5月至2017年3月病理确诊为FL的患者共22例,其中男性10例,女性12例,年龄22～88(中位年龄56)岁。患者化疗前、4程化疗后均行18F-FDG PET/CT显像。以Deauville评分4分为界点分成2组,行组间Kaplan-Meier生存分析。分别计算治疗前后SUVmax的差值(△SUVmax)及SUVmax下降百分比(△SUVmax%),ROC曲线计算最佳临界值并分组,行组间Kaplan-Meier生存分析。结果:Deauville评分<4分组较Deauville评分≥4分组2年无进展生存期(progress free survival,PFS)明显延长,且有统计学差异(P=0. 000)。22例患者进展12例(12/22,54. 5%),无进展10例(10/22,45. 5%)。进展组与无进展组△SUVmax分别为2. 8±3. 4、6. 9±2. 6,两者有统计学差异(P=0. 005);进展组与无进展组△SUVmax%分别为(29. 9±0. 35)%、(80. 6±0. 09)%,两者有统计学差异(P=0. 001)。结论:Deauville 5分法在中期化疗后评分对于预测FL患者预后有一定价值。
Objective:We aimed to investigate the prognostic value of Deauville 5-point scale(5PS) and △SUV in follicular lymphoma(FL).Methods:22 FL patients[10 males,12 females.Median age:56(22~88)years old]were retrospectively analyzed from May 2009 to March 2017,who had analyzable 18 F-FDG PET/CT scans performed before and after 4 courses of chemotheraphy.Survival functions were estimated by Kaplan-Meier method between patients with Deauville 5-point scale<4 and patients with Deauville 5-point scale≥4.ROC curves were used for determining the best cutoff value of △SUV max and △SUV max%in predicting progress free survival(PFS).Results:When applying the Deauville 5-point scale with a cutoff<4,the 24-month PFS was significantly longer than those applying a cutoff≥4(P=0.000).12 patients(12/22,54.5%)resulted disease progressed within 2 years follow-up,while 10 patients(10/22,45.5%)didn't result disease progressed.The mean values of△SUV max were 2.8±3.4 and 6.9±2.6 in progressed group and non-progressed group(P=0.005).The mean values of△SUV max%disease progressed were(29.9±0.35)%and(80.6±0.09)%in progressed group and non-progressed group(P=0.001).Conclusion:Deauville 5-point scale could assess prognostic value in FL patients after medium-term chemotherapy.
作者
韩磊
赵晋华
陈香
Han Lei;Zhao Jinhua;Chen Xiang(Department of Nuclear Medicine,Shanghai General Hospital of Shanghai Jiaotong University,Shanghai 200080,China)
出处
《现代肿瘤医学》
CAS
2019年第3期477-480,共4页
Journal of Modern Oncology
