摘要
目的探讨支气管肺炎患儿血清高敏C-反应蛋白(hs-CRP)、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平变化及临床意义。方法选取2015年3月到2017年3月收治的支气管肺炎患儿240例,患儿均给予基础对症治疗,采用免疫比浊法检测血清hs-CRP、IL-6、TNF-α水平,并与30例健康儿童作比较。结果支气管肺炎患儿血清hs-CRP、IL-6、TNF-α水平明显高于健康儿童,差异有统计学意义(P <0. 05);支气管肺炎患儿治疗后有效200例(83. 33%),无效40例(16. 67%);在血清hs-CRP、IL-6、TNF-α水平方面,支气管肺炎患儿治疗后明显低于治疗前,治疗有效者治疗后明显低于治疗无效者,差异有统计学意义(P <0. 05),治疗有效者治疗后与健康儿童比较,差异无统计学意义(P> 0. 05)。Pearson相关性分析结果显示,血清hs-CRP水平与血清IL-6、TNF-α水平呈正相关(P <0. 05)。结论血清hs-CRP、IL-6、TNF-α水平与小儿支气管肺炎的发生发展及病情转归有关,检测三者血清水平变化对了解患儿病情和指导治疗具有重要的参考价值。
Objective To investigate the changes and clinical significance of serum high sensitive C reactive protein (hs-CRP),interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in children patients with bronchopneumonia. MethodsA total of 240 children patients with bronchopneumonia who were treated in our hospital from March 2015 and March 2017 were enrolled in the study (observation group). All the patients were treated by basic symptomatic treatment.The serum levels of hs-CRP,IL-6 and TNF-α were detected by immunoturbidity method,which were and compared with those of 30 healthy children (control group). ResultsThe serum levels of hs-CRP,IL-6 and TNF-α in observation group were significantly higher than those in control group ( P <0.05).After treatment,200 cases (83.33%) were effective and 40 cases (16.67%) were invalid in observation group.After treatment the serum levels of hs-CRP,IL-6 and TNF-α in observation group were significantly lower than those before treatment ( P <0.05),which in the patients with effectiveness were significantly lower than those of patients without effectiveness after treatment ( P <0.05). However there were no significant differences in the serum levels of the indexes between the patients with effectiveness and healthy children ( P >0.05).Pearson correlation analysis showed that the serum levels of hs-CRP were positively correlated with those of IL-6 and TNF-α( P < 0.05 ). ConclusionThe serum levels of hs-CRP,IL-6 and TNF-α are related to the pathogenesis, development and prognosis of bronchopneumonia in children,and the detection of the change of serum levels of the three indexes has important reference value for understanding the patient’s disease condition and guiding the treatment.
作者
刘宪河
LIU Xianhe(People’s Hospital of Chengwu County,Shandong,Chengwu 274200,China)
出处
《河北医药》
CAS
2019年第1期99-102,共4页
Hebei Medical Journal
关键词
支气管肺炎
高敏C-反应蛋白
白介素6
肿瘤坏死因子-α
bronchopneumonia
high sensitive C reactive protein
interleukin 6
tumor necrosis factor-alpha
