摘要
目的:探讨ER、PR、Her-2及Ki-67在乳腺癌原发灶和前哨淋巴结转移灶中的表达变化及其临床病理意义。方法:收集50例具有乳腺癌原发灶和前哨淋巴结转移灶的病例,采用免疫组化及原位杂交分析原发灶和前哨淋巴结转移灶中ER、PR、Her-2及Ki-67的表达有无差异。结果:ER在乳腺癌原发灶和SLN转移灶中表达一致率为100%。PR原发灶和转移灶一致率为92%,变化率为8%,Her-2原发灶和转移灶一致率为96%,变化率为4%,表达变化均无统计学意义(P> 0.05)。Ki-67在乳腺癌原发灶表达率为(30.3±20.2)%,SLN转移灶表达率(25.1±17.6)%,差异具有统计学意义(P <0.05); Ki-67原发灶和转移灶表达一致率为70%,变化率为30%,但表达变化无统计学意义(P> 0.05)。补充腋窝淋巴结阳性率在原发灶高表达、SLN转移灶中变为低表达组22.2%(2/9)明显低于无变化组62.5%(15/24),差异具有统计学意义(P=0.04)。结论:原发灶基本能反应SLN转移灶ER、PR、Her-2表达状态,但针对个体而言,SLN转移灶分子状态重新评价仍有益。Ki-67在SLN转移灶表达率降低,原发灶高表达而SLN转移灶变为低表达可能预测补充腋窝淋巴结的低转移率。
Objective:To explore the expression and difference of ER,PR,Her-2 and Ki-67 between primary breast cancer and synchronous sentinel lymph node metastasis. Methods:50 cases of primary breast cancer with synchronous sentinel lymph node metastases were collected.The expression and difference of ER,PR,Her-2 and Ki-67 between primary breast cancer and sentinel lymph node metastasis were discussed by immunohistochemistry and in situ hybridization. Results:The consistent rate of ER between primary breast cancer and SLN metastasis was 100%.The consistent rates of PR and Her-2 between primary breast cancer and SLN metastasis were 92% and 96%,and the inconsistency rates were 8% and 4%,and there were no statistically significant differences( P >0.05).The expression rate of Ki-67 in primary breast cancer was (30.3±20.2)%,and (25.1±17.6)% in SLN metastasis,the difference was statistically significant ( P <0.05).The consistent rates of Ki-67 between primary breast cancer and SLN metastasis were 70%,and the inconsistency rates were 30%,but there was no statistically significant difference( P >0.05).The positive rate of axillary lymph nodes in the high expression of primary tumors but low in SLN metastasis group was 22.2%(2/9),which was significantly lower than that in the non change group 62.5%(15/24),and the difference was statistically significant ( P =0.04). Conclusion:The ER,PR and Her-2 status of primary foci can represent the expression of SLN metastasis basically,however,reevaluate the molecular status of SLN metastases will be beneficial for individuals.The expression of Ki-67 in SLN metastasis decreased,and could predict lower positive status of axillary lymph node possibly.
作者
王耀辉
高丽丽
王晨曦
刘春样
章宜芬
Wang Yaohui;Gao Lili;Wang Chenxi;Liu Chunyang;Zhang Yifen(Department of Pathology,Jiangsu Province Hospital of Chinese Medicine,Jiangsu Nanjing 210029,China)
出处
《现代肿瘤医学》
CAS
2019年第6期959-963,共5页
Journal of Modern Oncology
基金
江苏省中医院院级课题(编号:Y17063)
关键词
乳腺癌
前哨淋巴结
雌激素受体
孕激素受体
人表皮生长因子受体2
KI-67
表达差异
breast cancer
sentinel lymph node
estrogen receptor
progesterone receptor
human epidermal growth factor receptor 2
Ki-67
differential expression
