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国内丁苯肽治疗急性缺血性脑卒中机制的应用研究 被引量:6

Study on the Application of Domestic Butyl Phenyl Peptide in the Treatment of Acute Ischemic Stroke
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摘要 脑血管病在老年患者中多见,且该疾病的发病率呈逐年上升趋势。急性缺血性脑卒中在临床被称为急性脑梗死,其主要是由于人体某一支血管被阻塞后所致血流供应障碍,使其组织出现缺氧、缺血,导致人体脑细胞发生电化学级联瀑布样反应,其能够与受损细胞内信号通路形成偶联活化,导致疾病发展成为不可逆性。目前临床对于该疾病通常以药物治疗为主,其中丁苯肽是治疗脑血管病的常见药物,其能够使人体侧支循环得到提高和改善,对神经凋亡具有抑制作用,能够将人体氧自由基有效清除,使其炎症反应明显降低,对急性缺血性脑卒中起到明显治疗效果。 Cerebrovascular disease is more common in elderly patients, and the incidence of this disease is increasing year by year. Acute ischemic stroke is called acute cerebral infarction in the clinic. It is mainly caused by blood supply disorder caused by obstruction of a certain blood vessel in the human body, causing hypoxia and ischemia in tissues, resulting in electricity generation in human brain cells. A chemical cascade cascade-like reaction that is capable of coupling activation with signaling pathways in damaged cells, leading to irreversible disease progression. At present, the disease is usually treated mainly by drugs. Among them, butyl phenyl peptide is a common drug for treating cerebrovascular diseases, which can improve and improve the collateral circulation of the human body, inhibit the neuronal apoptosis, and can free the body oxygen. Effective removal of the base, resulting in a significant reduction in inflammatory response, has a significant therapeutic effect on acute ischemic stroke.
作者 王珊珊 WANG Shan-shan(Department of Neurology,Tianjin Occupational Disease Prevention and Control Institute,Tianjin 300011,China)
出处 《医学信息》 2019年第9期58-60,共3页 Journal of Medical Information
关键词 丁苯肽 神经凋亡 急性缺血性脑卒中 Butyl Phenyl Peptide Neuronal apoptosis Acute ischemic stroke
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