摘要
目的:探究伏格列波糖联合二甲双胍对青年2型糖尿病(T2DM)患者血清生长激素释放肽(Ghrelin)和视黄醇结合蛋白(RBP4)水平的影响。方法:将82例青年T2DM患者按随机数字表法分为对照组和研究组,每组41例。对照组给予二甲双胍治疗,研究组给予二甲双胍联合伏格列波糖治疗。比较两组不良反应发生率、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、2 h餐后血糖(2 h PG)及血清Ghrelin、RBP4水平。结果:研究组HbA1c、FBG、2 h PG改善情况明显优于对照组,血清Ghrelin水平明显高于对照组,血清RBP4水平明显低于对照组,差异均有统计学意义(均P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:伏格列波糖联合二甲双胍治疗可明显改善青年T2DM患者血糖指标和血清Ghrelin、RBP4水平,且安全性较好。
Objective: To investigate the effect of voglibose combined with metformin on the serum Ghrelin and retinol binding protein 4(RBP4) levels in youth patients with type 2 diabetes. Methods: A total of 82 youth patients with type 2 diabetes were randomly divided into a control group and a study group,with 41 cases in each group. The patients in the control group were treated with metformin,and those in the study group were treated with voglibose combined with metformin.The incidence of adverse reaction,fasting blood glucose (FBG),glycosylated hemoglobin (HbA1c),2-hour postprandial blood glucose (2 h PG) and serum levels of Ghrelin and RBP4 were compared between the two groups. Results: The HbA1c,FBG and 2 h PG were significantly improved in the study group compared with the control group after treatment (P<0.05).The serum level of Ghrelin in the study group was higher than that in the control group,while the serum RBP4 level was significantly lower (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion: Voglibose combined with metformin could markedly improve blood glucose level and the serum levels of Ghrelin and RBP4 in youth patients with type 2 diabetes,and was safe.
作者
郑晓青
姚铠涛
陈燕云
刘茉云
Zheng Xiaoqing;Yao Kaitao;Chen Yanyun;Liu Moyun(Shantou University Hospital,Shantou 515063,China;The Second Affiliated Hospital of Shantou University Medical College,Shantou 515042,China;The People’s Hospital of Shantou Jinping District Affiliated,Shantou 515041,China)
出处
《广西医科大学学报》
CAS
2019年第4期578-581,共4页
Journal of Guangxi Medical University
