摘要
目的:探讨中性粒细胞/淋巴细胞比值(NLR)对多发性骨髓瘤(MM)患者预后评估的价值。方法:以65例初发MM患者和83例同期健康体检者,根据血常规结果计算得出NLR,比较2者差异;并以中位数为临界值,将病例组患者分为低NLR组(NLR <2.34)和高NLR组(NLR≥2.34),分析2组患者在年龄、性别、血清钙(Ca)、血清β2微球蛋白(β2-MG)、白蛋白(Alb)、血肌酐(Cr)、血红蛋白(Hb)、红细胞分布宽度(RDW)及乳酸脱氢酶(LDH)水平的差异;比较高NLR组和低NLR组患者生存率的差异;单因素及COX多因素回归分析各指标与MM患者预后的关系。结果:MM患者NLR水平高于对照组(z=-2.415,P水平偏高,但差异无统计学意义;单因素分析结果显示,NLR、β2-MG及ALB是MM患者预后的危险因素;多因素分析显示,NLR及Alb水平是影响MM患者预后的独立危险因素。结论:初诊MM患者NLR升高提示预后不良,是影响预后的独立危险因素。
Objective:To study the value of neutrophil/lymphocyte ratio(NLR)in the evaluation of prognosis of patients with multiple myeloma(MM).Methods:NLR was calculated on the basis of the blood routine examination results of 65 patients with primary MM(MM group)and 83 persons receiving physical examination as control group,and the difference in 2 group was compared;moreover according to the median as threshold,the patients were divided into low NLR group(NLR<2.34)and high NLR group(NLR≥2.34);the differences of age,sex,serum calcium β2(Ca),microglobulin(β2-MG),albumin(Alb),serum creatinine(Cr),hemoglobin(Hb),red blood cell distribution width(RDW)and lactate dehydrogenase(LDH)in 2 group were analyzed,and the survival rate was compared between the high and low-NLR group.Results:the NLR of MM patients was statistically significantly higher than that of the control group(z=-2.415,P<0.05).Compared with the low NLR group,the β2-MG and Cr levels of patients in the high NLR group seemed higher,but the difference was not statistically significant.The single-factor analysis showed that NLR,β2-MG and Alb levels were risk factors for the prognosis of MM patients,and the multi-factor analysis showed that NLR and Alb level were independent risk factors influencing the prognosis of MM patients.Conclusion:NLR elevation in patients with primary diagnosis of MM indicates a poor prognosis,which is an independent risk factor affecting the prognosis.
作者
孙延庆
李青芬
张启科
魏小芳
冯友繁
SUN Yan-Qing;LI Qing-Fen;ZHANG Qi-Ke;WEI Xiao-Fang;FENG You-Fan(Department of Hematology,Gansu Provincial People's Hospital,Lanzhou 730000,Gansu Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2019年第2期489-493,共5页
Journal of Experimental Hematology
基金
甘肃省人民医院院内科研基金项目(编号:17GSSY2-2)
