摘要
目的探讨应用左金丸合小柴胡汤加减结合西药治疗肝胃郁热型慢性胃炎的临床效果。方法选择本院2015年3月至2017年12月慢性胃炎患者140例,随机分为对照组(70例)和研究组(70例),对照组进行西药常规治疗,研究组在对照组患者治疗基础上应用左金丸合小柴胡汤加减治疗。评估临床疗效、症状、胃黏膜组织恢复时间、治疗前后症状评分和胃黏膜病理评分。结果研究组患者总有效率为91%(64/70),高于对照组79%(55/70),差异具有统计学意义(P<0.05)。研究组患者胃炎症状消失时间、胃黏膜组织学恢复时间分别为(10.6±0.8)d和(17.4±1.2)d,均短于对照组(13.6±0.8)d和(21.6±1.0)d,差异具有统计学意义(P<0.05)。研究组治疗后胃痛、嗳气反酸、上腹胀、纳呆食少及胃病理评分为(0.41±0.24)分、(0.76±0.29)分、(0.79±0.28)分、(0.62±0.29)分和(2.03±0.57)分,低于对照组(0.96±0.22)分、(1.34±0.25)分、(1.37±0.28)分、(1.23±0.27)分和(3.15±0.54)分,差异有统计学意义(P<0.05)。2组不良反应比较,差异无统计学意义(P>0.05)。结论应用左金丸合小柴胡汤加减结合西药治疗肝胃郁热型慢性胃炎,临床疗效、症状及胃黏膜病理改善显著,能够显著缩短症状和胃黏膜组织恢复时间,且具有较好的安全性。
Objective To investigate the clinical efficacy of Zuojin Pill plus modified Xiaochaihu Decoction and western medicine in treatment of chronic gastritis arising from liver and stomach heat stagnation. Methods A total of 140 patients with chronic gastritis in our hospital between March 2015 and December 2017 were enrolled and randomly divided into a control group(n=70) and a treatment group(n=70). The control group was treated with western medicine. The treatment group was treated with Zuojin Pill plus modified Xiaochaihu decoction in addition to the therapy given for the control group. The clinical efficacy, symptoms and time to recovery of gastric mucosa tissue,symptom scores at baseline and after treatment, and pathological scores of gastric mucosa were evaluated. Results The overall rate of effectiveness in the study group was 91%(64/70), higher than that in the control group [78.6%(55/70] with statistical difference(P<0.05). The time to resolution of gastritis and the time to recovery of gastric mucosa in the study group were(10.6±0.8) d and(17.4±1.2) d, respectively, which were significantly shorter than(13.6 ±0.8) d and(21.6±1.0) d, respectively, in the control group(P<0.05). After treatment, the scores of stomachache, acidic regurgitation, upper abdominal distension, anorexia and gastric pathology scores in the study group were(0.41 ±0.24),(0.76±0.29),(0.79±0.28),(0.62±0.29) and(2.03±0.57), which were significantly lower(0.96±0.22),(1.34±0.25),(1.37±0.28),(1.23±0.27) and(3.15±0.54), respectively, in the control group(P<0.05). There was no statistically significant difference in adverse reactions between the two groups(P>0.05). Conclusion For treatment of chronic gastritis arising from liver and stomach heat stagnation, Zuojin pill plus modified Xiaochaihu decoction and western medicine may result in significant improvements in clinical efficacy, symptoms and gastric mucosal pathology, faster resolution of symptoms and shorter time to recovery of gastric mucosa, meanwhile with satisfactory safety.
作者
刘旭昭
闫伟
林芳冰
马丽然
Liu Xuzhao;Yan Wei;Lin Fangbing;Ma Liran(Department of Internal Medicine,Chaoyang District Hospital of Traditional Chinese Medicine,Beijing 100020,China)
出处
《中国药物与临床》
CAS
2019年第10期1609-1611,共3页
Chinese Remedies & Clinics
关键词
慢性胃炎
肝胃郁热型
左金丸
小柴胡汤
临床疗效
Chronic gastritis
Liver and stomach heat stagnation
Zuojin pill
Xiaochaihu decoction
Clinical efficacy
