摘要
目的乳腺癌已成为严重影响我国女性健康的恶性肿瘤之一。为获得更多更新的数据信息,本研究分析了我国2005-2013年女性乳腺癌死亡及疾病负担的时间趋势,为推进乳腺癌的预测和防控工作提供参考。方法根据我国2005-2013年肿瘤登记资料,获得女性乳腺癌粗死亡率,计算标化率、潜在减寿年(potential years of life lost,PYLL)和伤残调整生命年(disability adjusted life year,DALY),采用年度变化百分比(annual percent change,APC)模型分析其时间和年龄变化趋势。结果 2005-2013年女性乳腺癌死亡标化率从5.00/10万上升到6.55/10万,增加了31.00%,APC为5.47%,P=0.006,城市和农村的APC分别为5.64%和8.33%,P=0.004。死亡率随年龄的增长持续增加,60～64岁上升有统计学意义,APC为2.48%,P=0.010,城市和农村分别为2.56%和6.27%,P值分别为0.030和P=0.020。PYLL和DALY均随年龄的增长先升后降,PYLL的APC在60～64岁最高,APC=2.49%,P=0.010。DALY主要集中在50～64岁,APC有统计学意义的是40～44岁,APC=1.88%,P=0.020。结论中国女性乳腺癌在2005-2013年死亡及疾病负担均在增长,且以农村为主。我国应继续开展乳腺癌的防控,尤其对农村中年女性乳腺癌的防治工作亟待加强。
OBJECTIVE Breast cancer has become one of the cancers seriously affecting women’s health in China. In order to update data and obtain more information,this study analyzed the time trends of death and disease burden of female breast cancer in China from 2005to 2013,aimed to provide data reference for promoting the prediction and prevention of breast cancer.METHODS According to the cancer registration materials of China from 2005to 2013,got the crude mortality rate of female breast cancer,calculated the standardized rate,potential years of life lost(PYLL)and disability adjusted life year(DALY),and used the annual percentage change(APC)model to analyze the trends of time and age. RESULTS From 2005to 2013,the standardized mortality rate of female breast cancer increased from 5.00/105 to 6.55/ 105,with an increasing of 31.00%,APC was 5.47%(P=0.006),the APC of urban and rural were 5.64%and 8.33%(P=0.004)respectively.The mortality continued to increase with age and the 60-64years old increased significantly, APC was 2.48%(P=0.010),that of urban and rural were 2.56%(P=0.030)and 6.27%(P=0.020)respectively. PYLL and DALY increased firstly and then decreased with age,the APC of PYLL was the highest in the 60-64years old (APC=2.49%,P=0.010).DALY concentrated in 50-64years old.APC was significant in 40-44years old(APC= 1.88%,P=0.020).CONCLUSIONS The mortality and disease burden of female breast cancer in China increased rapidly during 2005-2013,mainly in rural areas.China should strengthen the prevention and control of breast cancer,especially for middle-aged women in rural.
作者
何家赓
侯建忠
闫贻忠
HE Jia-geng;HOU Jian-zhong;YAN Yi-zhong(Department of General Surgery,First Affiliated Hospital,Medical College of Shihezi University, Shihezi 832002,P.R.China;Department of Preventive Medicine,Medical College of Shihezi University,Shihezi 832002,P.R.China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2019年第8期523-528,共6页
Chinese Journal of Cancer Prevention and Treatment
基金
新疆生产建设兵团重大公共卫生专项(2100409)
关键词
女性乳腺癌
死亡率
疾病负担
时间趋势
female breast cancer
mortality
disease burden
time trend
