摘要
目的探讨实施辅助生殖技术(assisted reproductive technology,ART)后发生异位妊娠的危险因素,并提出相关干预措施。方法选取2014年6月至2017年9月在本院行ART后发生异位妊娠的患者82例纳入异位妊娠组,同期成功宫内妊娠的孕妇106例纳入宫内妊娠组,比较两组孕妇的临床资料,应用单因素及多因素Logistic回归分析探讨ART后异位妊娠发生的危险因素。结果两组孕妇不孕年限、原发不孕、男方因素、体质指数、移植胚胎个数、染色体异常比较均无明显差异(P_均> 0.05),而盆腔手术史、既往异位妊娠史、移植时子宫内膜厚度、排卵障碍、输卵管因素及子宫内膜异位症比较均有明显差异(P_均<0.05);多因素Logistic回归分析显示,盆腔手术史、移植时子宫内膜厚度、既往异位妊娠史、子宫内膜异位症、排卵障碍及输卵管因素均是ART后发生异位妊娠的独立危险因素(P_均<0.05)。结论在行ART前应对患者存在的危险因素进行详细评估,以降低ART后异位妊娠的发生率,改善妊娠结局。
Objective To explore the risk factors for ectopic pregnancy after assisted reproductive technology(ART)and propose relevant interventions.Method From June 2014 to September 2017,82 patients with ectopic pregnancy after implementation of ART in our hospital were included in ectopic pregnancy group,and 106 patients with successful intrauterine pregnancy were included in intrauterine pregnancy group.The clinical data of the two groups were compared,and the risk factors of ectopic pregnancy were investigated by single factor and multivariate Logistic regression analysis.Result There were no significant differences in infertility years,primary infertility,male factors,body mass index,number of transplanted embryos,and chromosomal abnormalities between the two groups(Pall>0.05).The history of pelvic surgery,previous history of ectopic pregnancy,endometrial thickness during transplantation,ovulation disorders,tubal factors and endometriosis comparison were significantly different(Pall<0.05).Multivariate Logistic regression analysis showed that history of pelvic surgery,endometrial thickness during transplantation,history of ectopic pregnancy,endometriosis,ovulation disorders and tubal factors were independent risk factors for ectopic pregnancy after ART(Pall<0.05).Conclusion The risk factors should be evaluated in detail before the implementation of ART to reduce the incidence of ectopic pregnancy and improve pregnancy outcomes.
作者
何桦
陈昀
杨小杰
HE Hua;CHEN Yun;YANG Xiao-jie(Department of Ultrasound Medicine,Tangshan Maternal and Child Health Hospital,Hebei,Tangshan 063000,China;Department of Gynaecology and Obstetrics,Tangshan Maternal and Child Health Hospital,Hebei,Tangshan 063000,China)
出处
《中国医学前沿杂志（电子版）》
2019年第4期78-80,共3页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
河北省2018年度医学科学研究重点课题计划(20181336)
关键词
辅助生殖技术
异位妊娠
危险因素
干预措施
Assisted reproductive technology
Ectopic pregnancy
Risk factors
Intervention measures
