摘要
目的:探讨低分子肝素钠联合川芎嗪注射液治疗早发型重度子痫前期并发妊娠期肾病综合征的疗效。方法:选取2012年3月至2018年9月秦皇岛市第二医院收治的早发型重度子痫前期并发妊娠期肾病综合征患者108例,根据随机数字表法分为对照组(55例)和观察组(53例)。两组患者均给予常规治疗,观察组患者在此基础上辅以低分子肝素钠联合川芎嗪注射液治疗。比较两组患者妊娠结局、围生儿结局、患者并发症发生情况及新生儿1 min和5 min Apgar评分的差异。结果:观察组患者终止妊娠时间明显长于对照组,差异有统计学意义(P<0.05)。观察组患者的胎盘质量、新生儿体质量明显高于对照组,胎儿生长受限率明显低于对照组,差异均有统计学意义(P<0.05);两组围生儿死亡率的差异无统计学意义(P>0.05)。观察组患者腹水、肾功能异常、胎盘早剥、子痫及产后出血的发生率明显低于对照组,差异均有统计学意义(P<0.05)。观察组中1 min和5 min Apgar评分≥7分新生儿所占比例明显高于对照组,差异均有统计学意义(P<0.05)。结论:低分子肝素钠联合川芎嗪注射液治疗早发型重度子痫前期并发妊娠期肾病综合征,可有效改善患者妊娠结局和围生儿结局,安全性较高。
OBJECTIVE: To probe into the efficacy of low molecular weight heparin sodium combined with ligustrazine injection in treatment of early onset severe pre-eclampsia complicated with nephrotic syndrome of pregnancy. METHODS: 108 patients with early-onset severe pre-eclampsia complicated with gestational nephrotic syndrome admitted to the Second Hospital of Qinhuangdao from Mar. 2012 to Sept. 2018 were selected and divided into control group(55 cases) and observation group(53 cases) according to random number table method. Both groups of patients were given routine treatment, and the patients in the observation group were treated with low molecular weight heparin sodium combined with ligustrazine injection. The differences in pregnancy outcome, perinatal outcome, patient complications, and neonatal 1 min and 5 min Apgar scores were compared between the two groups. RESULTS: The termination of pregnancy of observation group was significantly longer than that of the control group, with statistically significant difference(P<0.05). The quality of placenta and body mass of newborns of observation group were significantly higher than those of the control group, while the fetal growth restriction was significantly lower than the control group, with statistically significant differences(P<0.05);there was no statistical significance in difference of perinatal mortality between two groups(P>0.05). The incidences of ascites, abnormal renal function, placental abruption, eclampsia and postpartum hemorrhage of observation group were significantly lower than those of the control group, with statistically significant differences(P<0.05). The proportion of 1 min and 5 min Apgar scores≥7 of newborns of observation group was significantly higher than that in control group, with statistically significant difference(P<0.05). CONCLUSIONS: The combination of low molecular weight heparin sodium and ligustrazine injection in treatment of early onset severe pre-eclampsia complicated with nephrotic syndrome of pregnancy can effectively improve pregnancy outcomes and perinatal outcomes, with high safety.
作者
刘静
张志英
李丹
LIU Jing;ZHANG Zhiying;LI Dan(Dept.of Obstetrics, the Second Hospital of Qinhuangdao, Hebei Qinhuangdao 066600, China)
出处
《中国医院用药评价与分析》
2019年第4期419-421,425,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
秦皇岛市科学技术研究与发展计划(No.201602A 134)
关键词
低分子肝素钠
川芎嗪注射液
早发型重度子痫前期
妊娠期肾病综合征
Low molecular weight heparin sodium
Ligustrazine injection
Early onset severe pre-eclampsia
Nephrotic syndrome of pregnancy
