摘要
Xp11易位相关性肾细胞癌是存在TFE3基因易位的一种罕见肾细胞癌,与t(6;11)易位相关性肾细胞癌共同归类为MiT家族易位相关性肾细胞癌。随着免疫组织化学法、荧光原位杂交法、逆转录-聚合酶链反应以及RNA测序技术的发展和应用,越来越多的Xp11易位相关性肾细胞癌被诊断和研究,从而对于其在临床病理学、分子遗传学、临床治疗方面有了许多新的认识和进展。本文就近年来Xp11易位相关性肾细胞癌的研究进展进行综述。
Xp11 translocation renal cell carcinoma is a rare renal cell carcinoma subtype harboring a TFE3 translocation, which is grouped into the MiT family translocation renal cell carcinomas together with t (6;11) translocation renal cell carcinomas. With the development and application of immunohistochemistry, fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, and RNA sequencing, increasingly more Xp11 translocation renal cell carcinomas have been diagnosed and studied, and many new insights have been elucidated and advances have been made in clinicopathology, molecular genetics, and clinical treatment. The latest progress in Xp11 translocation renal cell carcinoma research is introduced and reviewed in this paper.
作者
杨博(综述)
孙保存(审校)
Bo Yang;Baocun Sun(Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China;Department of Pathology, Tianjin Medical University, Tianjin 300070, China;Department of Pathology Tianjin Medical University General Hospital, Tianjin 300052, China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2019年第8期421-423,共3页
Chinese Journal of Clinical Oncology
