摘要
目的探讨结肠癌患者血清血管内皮生长因子(VEGF)的表达及临床意义。方法检测50例结肠癌患者(结肠癌组)和50例健康体检者(对照组)血清VEGF水平,分析其与淋巴结转移、肝转移和TNM分期的关系。结果结肠癌组患者血清VEGF水平为(391.20±104.31) pg/ml,高于对照组的(119.71±38.24) pg/ml(P<0.01)。TNMⅠ、Ⅱ、Ⅲ和Ⅳ期患者血清VEGF水平为(122.14±29.84) pg/ml、(201.33±30.20) pg/ml、(311.64±47.32) pg/ml和(453.91±53.22) pg/ml,随着TNM分期的增加,VEGF水平升高(P<0.05)。有淋巴结转移患者血清VEGF水平为(333.94±54.39) pg/ml,高于无淋巴结转移患者的(169.78±42.36) pg/ml(P<0.01);有肝转移患者血清VEGF水平为(421.33±64.31) pg/ml,高于无肝转移患者的(153.35±39.39) pg/ml(P<0.01)。结论结肠癌患者血清VEGF表达水平明显升高,可能与肿瘤细胞浸润、转移有关。
Objective To investigate the expression and clinical significance of serum vascular endothelial growth factor(VEGF) in the patients with colon cancer.Methods Serum VEGF level was detected in 50 colon cancer patients(group A) and 50 healthy people(group B).The relationship of serum VEGF level and lymph node metastasis,hepatic metastasis and TNM stage was analyzed.Results Serum VEGF level was higher in group A than that in group B [(391.20±104.31) pg/ml vs.(119.71±38.24) pg/ml](P<0.01).Serum VEGF levels in the patients with TNM stage Ⅰ,Ⅱ,Ⅲ and Ⅳ were(122.14±29.84) pg/ml,(201.33±30.20) pg/ml,(311.64±47.32) pg/ml and(453.91±53.22) pg/ml,which were increased with the increase of TNM stage(P<0.05).Serum VEGF level was higher in the patients with lymph node metastasis than that in those without [(333.94±54.39) pg/ml vs.(169.78±42.36) pg/ml](P<0.01).Serum VEGF level was higher in the patients with hepatic metastasis than that in those without [(421.33±64.31) pg/ml vs.(153.35±39.39) pg/ml](P<0.01).Conclusion Serum VEGF level in the patients with colon cancer is significantly increased,which may be related to the infiltration and metastasis of tumor cells.
作者
刘斌
LIU Bin(Department of Laboratory Medicine,Tianjin Binhai New Area Dagang Hospital,Tianjin 300270, CHINA)
出处
《江苏医药》
CAS
2019年第5期480-482,共3页
Jiangsu Medical Journal
关键词
血管内皮生长因子
结肠癌
TNM分期
Vascular endothelial growth factor
Colon cancer
TNM stage
