摘要
目的采用Meta分析的方法探讨亚洲人群睡眠时间与卒中发病风险的关系。方法以睡眠时间(sleep duration)、卒中(stroke)、脑血管事件(erebrovascular event)为检索词,检索中国知网、万方数据知识服务平台、中国生物医学文献数据库、维普中文生物医学期刊数据库、PubMed、Embase和Web of science数据库,时间从各数据库建库至2018年4月,系统收集在此期间发表的有关亚洲人群睡眠时间与卒中发病风险关系的文献,文献类型为观察性研究,包括横断面研究、病例对照研究和队列研究。由2名研究员独立筛选文献、提取数据和评价纳入文献的质量。采用Stata12.0软件进行Meta分析。结果最终纳入18篇文献,共包含研究对象658 778例。Meta分析结果表明,短睡眠时间与卒中发病风险不相关(OR=1.08,95%CI:0.96~1.23,Z=1.27,P=0.205),长睡眠时间与卒中发病风险呈正相关(OR=1.61,95%CI:1.42~1.83,Z=7.49,P< 0.001)。短睡眠时间和卒中发病相关性的分析中,新加坡人群的短睡眠时间增加卒中发病风险,其他研究结果均不相关;长睡眠时间和卒中发病的相关性分析中,除病例对照研究的合并结果和韩国人群研究的合并结果提示长睡眠时间与卒中发病风险不相关外,其他研究结果均提示长睡眠时间增加卒中的发病风险。结论短睡眠时间不是亚洲人群卒中发病的危险因素,长睡眠时间是亚洲人群卒中发病的危险因素。
Objective To investigate the relationship between sleep duration and the risk of stroke in Asian populations. Methods Using duration of sleep, stroke and cerebrovascular event as search terms, we searched the China National Knowledge Internet(CNKI), Wanfang, Chinese BioMedical Literature(CBM), Vip Citation Databases(VIP), PubMed, EMBASE and Science Citation Index databases from the time of database construction to April 1, 2018.Observational studies including cross-sectional studies, case-control studies and cohort studies that aimed to investigate the relationship between sleep duration and the risk of stroke in Asian populations were collected.Two investigators independently screened the literature, extracted data and assessed the quality of included studies.All analyses were performed by using the Stata 12.0 software. Results A total of 18 studies, including 658 778 participants, were included in this meta-analysis.Pooled results showed that short sleep duration was not associated with increased risk of stroke(OR=1.08, 95%CI: 0.96-1.22, Z=1.27, P=0.205), but long sleep duration was associated with increased risk of stroke(OR=1.61, 95%CI: 1.42-1.83, Z=7.49, P<0.001). Subgroup analysis showed that short sleep duration was correlated with a high risk of stroke only in the Singaporean population while it was not the case in other Asian populations, and long sleep duration was correlated with a high risk of stroke in many studies except in pooled results of case-control studies and pooled research results concerning the Korean population. Conclusions Long but not short sleep duration is a risk factor for the incidence of stoke in Asian populations.
作者
王静
曹剑
徐伟豪
于生元
Wang Jing;Cao Jian;Xu Weihao;Yu Shengyuan(School of Medicine,Nankai University,Tianjin 300071,China;Department of Neurology,Chinese People's Liberation Army General Hospital,Beijing 100853,China;Department of Geriatric Cardiology,Chinese People's Liberation Army General Hospital,National Clinical Research Center for Geriatric Diseases,Beijing 100853,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2019年第6期691-694,共4页
Chinese Journal of Geriatrics
