摘要
疼痛在本质上是一种不愉快的体验,具有通过促进动机和学习来保护机体的特征。厌恶状态的缓解(包括疼痛的缓解)是有奖赏性质的。对疼痛的厌恶以及疼痛缓解获得的奖赏,都由具有奖赏/动机特性的中脑-边缘-皮层环路编码。本文综述了一些从动物模型以及人体神经影像研究获得的疼痛机制以及针刺对奖赏/动机环路影响的研究结果。此外,笔者还建议借助神经影像技术追踪介导针刺作用的大脑区域,并将脑奖赏/动机环路对针刺的反应作为一种镇痛功效判定的客观指标,为今后更加深入地研究针刺改善慢性痛的中枢机制提供帮助。
Pain is inherently unpleasant and has the characteristic of protecting the body by promoting motivation and learning.Relief from aversion(including pain relief)is rewarding.The aversion to pain and reward from pain relief are encoded by brain mesocorticolimbic circuits characterized by reward/motivation.This paper reviews the research findings about the effect of pain and acupuncture on reward/motivation circuits derived from animal models and human neuroimaging.It is further suggested that neuroimaging techniques may be used to track brain regions that mediate acupuncture effect,and the response of reward/motivation circuits to acupuncture could be used as an objective indicator of analgesic efficacy.It may provide help for further study on the brain mechanism of acupuncture in improving chronic pain.
作者
胡玲
HU Ling(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences, Beijing 100700,China)
出处
《针刺研究》
CAS
CSCD
北大核心
2019年第6期465-468,共4页
Acupuncture Research
基金
国家自然科学基金资助项目(No.81574085)
关键词
奖赏
动机
疼痛
针刺
Reward
Motivation
Pain
Acupuncture
