摘要
目的:探讨丹红+小剂量糖皮质激素治疗重症肺炎合并心肌损伤的临床效果。方法:选择本院收治的重症肺炎合并心肌损伤患者88例,随机分为对照组、研究组各44例。对照组接受常规西医+小剂量糖皮质激素治疗,研究组在对照组基础上加入丹红注射液治疗,持续2周。对比两组治疗前、治疗1周后、治疗2周后,外周血血气指标水平[PH值、氧分压(PaO2)、二氧化碳分压(PaCO2)]及血清炎症介质[白介素-1(IL-1)、白介素-17(IL-17)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、单核细胞趋化蛋白1(MCP-1)]、氧化应激指标[晚期蛋白氧化产物(AOPP)、脂质过氧化氢(LHP)、总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)]、心肌损伤标志物[乳酸脱氢酶(LD)、肌钙蛋白Ⅰ(TnI)、肌红蛋白(Mb)]含量的差异。结果:治疗前两组外周血血气指标水平,血清炎症介质、氧化应激指标、心肌损伤标志物含量的差异无统计学意义(P>0.05)。治疗1、2周后,研究组外周血PH值、PaO2的水平高于对照组,PaCO2的水平低于对照组;IL-1、IL-17、CRP、TNF-α、MCP-1的含量低于对照组;AOPP、LHP的含量低于对照组,T-AOC、SOD的含量高于对照组;LD、TnI、Mb的含量低于对照组(P<0.05)。结论:重症肺炎合并心肌损伤患者接受丹红+小剂量糖皮质激素治疗,可有效减轻机体炎症应激状态及心肌损伤程度。
Objective: To investigate the clinical effect of Danhong + low dose glucocorticoid in the treatment of severe pneumonia combined with myocardial injury. Methods: 88 severe pneumonia patients complicated with myocardial injury admitted to our hospital between December 2016 and December 2018 were divided into the control group (n=44) and the study group (n=44) by random number table method. Control group received conventional western medicine + low-dose glucocorticoid treatment, study group were treated with Danhong injection on the basis of the treatment for control group, and the treatment lasted for 2 weeks. The differences in peripheral blood levels of blood gas indexes [PH value, oxygen partial pressure (PaO2) and CO2 partial pressure (PaCO2)] as well as serum contents of inflammatory mediators [interleukin-1 (IL-1), interleukin-17 (IL-17), C-reactive protein (CRP), tumor necrosis factor α(TNF-α) and monocyte chemoattractant protein (MCP)], oxidative stress indexes [advanced oxidation protein product (AOPP), lipid hydroperoxide (LHP), total antioxidant capacity (T-AOC) and superoxide dismutase (SOD)] and myocardial injury markers [lactate dehydrogenase (LD), troponin I (TnI) and myoglobin (Mb)] were compared between the two groups of patients before treatment, after 1 week of treatment and after 2 weeks of treatment. Results: Before treatment, there were no statistically significant differences in peripheral blood levels of blood gas indexes as well as serum contents of inflammatory mediators, oxidative stress indexes and myocardial injury markers between the two groups (P>0.05). After 1 week and 2 weeks of treatment, peripheral blood PH value and PaO2 levels in the study group were higher than those in the control group, while PaCO2 levels were lower than those in the control group;IL-1, IL-17, CRP, TNF-α and MCP-1 contents were lower than those in the control group;AOPP and LHP contents were lower than those in the control group, while T-AOC and SOD contents were higher than those in the control group;LD, TnI and Mb contents were lower than those in the control group (P<0.05). Conclusion: Danhong + low-dose glucocorticoid therapy can effectively reduce the inflammatory stress and myocardial injury in severe pneumonia patients complicated with myocardial injury.
作者
冀国发
任徽
JI Guofa;REN Hui(Respiratory Medicine Department, the First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi Province, 710000, China)
出处
《海南医学院学报》
CAS
2019年第12期886-891,共6页
Journal of Hainan Medical University
基金
陕西省社会发展领域重点项目(2018SF-071)~~
关键词
重症肺炎
心肌损伤
丹红注射液
糖皮质激素
Severe pneumonia
Myocardial injury
Danhong injection
Glucocorticoid
