摘要
目的分析肺癌患病的危险因素,为预防控制肺癌提供依据。方法采用病例对照研究方法,选取2015年1月—2017年6月绍兴市461例新发肺癌病例为病例组,采用频数匹配法选取与病例年龄、性别构成相近且同地居住的600名正常居民为对照组;通过问卷调查收集人口学特征、慢性病家族史、既往疾病史和行为因素资料,采用Logistic回归模型分析肺癌患病的危险因素。结果多因素Logistic回归分析结果显示,调整性别、年龄后,有恶性肿瘤家族史(OR=6.606,95%CI:3.439~12.689)、有肺部疾病患病史(OR=2.836,95%CI:1.208~6.659)、生活和工作紧张程度一般/紧张(OR=2.485,95%CI:1.830~3.376)、每周食用新鲜蔬菜天数<5天(OR=3.116,95%CI:2.470~3.930)和现在吸烟/偶尔吸烟/已戒烟(OR=6.029,95%CI:3.716~9.783)是肺癌患病的危险因素。进一步分析吸烟与肺癌患病的关联显示,调整年龄、性别、恶性肿瘤家族史、肺部疾病患病史、生活和工作紧张程度及每周食用新鲜蔬菜天数后,与已戒烟≥10年相比,<10年是肺癌患病的危险因素(OR=4.751,95%CI:2.404~9.386)。结论恶性肿瘤家族史、肺部疾病患病史、生活和工作中紧张程度高、每周食用新鲜蔬菜天数<5天和吸烟是肺癌患病的危险因素。
Objective To analyze the risk factors for lung cancer and to provide scientific evidence for prevention of lung cancer. Methods A total of 461 newly diagnosed patients with primary lung cancer from January 2015 to June 2017 in Shaoxing were selected as the case group. Six hundred healthy residents with the same residence,distribution of gender and age as the cases were selected as the control group by frequency matching method. A questionnaire survey was conducted to collect demographic characteristics,family history of major chronic diseases,disease history and behavioral factors. The method of case-control study and multivariate logistic regression model were used for statistical analysis of the risk factors for lung cancer. Results The results of multivariate logistic regression analysis showed that after adjusting for age and gender,family history of cancer(OR=6.606,95%CI:3.439-12.689),history of lung diseases(OR=2.836,95%CI:1.208-6.659),high level of stress(OR=2.485,95%CI:1.830-3.376),low consumption of fresh vegetables(OR=3.116,95%CI:2.470-3.930)and smoking(OR=6.029,95%CI:3.716-9.783)were risk factors for lung cancer;after adjusting for age,gender,family history of cancer,history of lung diseases,stress levels and consumption of fresh vegetables,quitting smoking for less than ten years was a risk factor for lung cancer(OR=4.751,95%CI:2.404-9.386)compared with quitting smoking for ten years or above. Conclusion Family history of cancer,history of lung diseases,high level of stress,low consumption of fresh vegetables and smoking were risk factors for lung cancer.
作者
方益荣
马岩
许树红
裴迎新
FANG Yi-rong;MA Yan;XU Shu-hong;PEI Ying-xin(Shaoxing Center for Disease Control and Prevention,Shaoxing,Zhejiang 312000,China)
出处
《预防医学》
2019年第7期649-652,共4页
CHINA PREVENTIVE MEDICINE JOURNAL
基金
浙江省科技厅钱江人才计划(2013R10078)
绍兴市公益性技术应用研究计划(2014B70082)
关键词
肺癌
危险因素
病例对照研究
Lung cancer
Risk factors
Case-control study
