摘要
目的探讨左旋甲状腺素钠对甲状腺功能减退症患者心肌酶谱、血脂水平及甲状腺功能的影响。方法选取2015年4月至2017年4月收治的64例甲状腺功能减退症患者为研究对象,按照随机数字法分为观察组和对照组,每组32例。对照组给予甲状腺片治疗,观察组给予左旋甲状腺素钠治疗。2组连续治疗8个月,比较患者心肌酶谱[天门冬氨酸氨基转移酶(AST)、肌酸磷酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)]、血脂水平[胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]及甲状腺功能[游高三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]等指标。结果观察组患者治疗总有效率为96.8%明显高于对照组的78.1%,差异有统计学意义(P<0.05)。治疗后2组AST、CK、CK-MB、LDH指标均显著降低,观察组AST、CK、CK-MB和LDH明显低于对照组,差异有统计学意义(P<0.05)。治疗后TC、TG、LDL水平较治疗前显著降低,差异有统计学意义(P<0.05);观察组TC、TG、LDL水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后2组甲状腺功能较治疗前均得到显著改善,观察组FT3、FT4、TT4显著高于对照组,差异均有统计学意义(P<0.05);观察组TSH显著低于对照组,差异有统计学意义(P<0.05)。结论左旋甲状腺素钠有益于改善甲状腺功能减退症患者的心肌酶谱紊乱,降低血脂水平,促进甲状腺功能恢复,疗效显著,临床价值高,可在临床上推广使用。
Objective To investigate the effects of thyroxine on myocardial zymogram,blood lipid levels and thyroid function in patients with hypothyroidism. Methods A total of 64 patients with hypothyroidism who were treated in our hospital from April 2015 to April 2017 were enrolled in the study,who were divided into observation group(n = 32) and control group(n = 32) according to the random number method. The patients in control group were treated by oral thyroid tablets,however,the patients in observation group were treated by levothyroxine,with a treatment course of 8 months for both groups. The indexes including myocardial enzymes,blood lipids and thyroid function were observed and compared between the two groups.Results The total effective rate in observation group was significantly higher than that in control group(96. 8% vs 78. 1%,P < 0. 05). After treatment the myocardial enzyme levels including AST,CK,CK-MB and LDH were obviously decreased in both groups,moreover,which in observation group were significantly lower than those in control group(P < 0. 05). Afte treatment the levels of TC,TG and LDL were obviously decreased in both groups,moreover,which in observation group were significantly lower than those in control group(P < 0. 05). Moreover the thyroid function of patients in both groups was significantly improved after treatment(P < 0. 05). The levels of FT3,FT4 and TT4 in observation group were significantly higher than those in control group(P < 0. 05),however,the TSH levels in observation group were significantly lower than those in control group(P < 0. 05). Conclusion The thyroxine has the potential to effectively improve myocardial zymogram disorder in patients with hypothyroidism,which can decrease the blood lipid levels,and promote thyroid function recovery,with obvious cilinical curative effects,therefor,which can be used widely in clinical practice.
作者
李衍记
LI Yanji(Department of Endocrinology,New Journey hospital of Yanzhou Mining Industry Group,Shandong,Zoucheng 273500,China)
出处
《河北医药》
CAS
2019年第13期2004-2006,2011,共4页
Hebei Medical Journal
