摘要
目的研究河朔荛花Wikstroemia chamaedaphne Meisn.的化学成分。方法河朔荛花70%乙醇提取物采用硅胶柱、凝胶柱、重结晶、高效制备液相进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到20个化合物,分别鉴定为piperitol(1)、forsythialan A(2)、桉脂素(3)、芝麻素(4)、torilin(5)、3,4-二香草基四氢呋喃(6)、丁香脂素(7)、落叶松脂醇(8)、松脂素(9)、松脂酚-4-O-β-D-葡萄糖苷(10)、圣草酚(11)、圣草素-7,3′-二甲醚(12)、咖啡酸乙酯(13)、咖啡酸甲酯(14)、blumenol B(15)、5,7-二羟基色原酮(16)、5-羟基-7-甲氧基色原酮(17)、柚皮素(18)、反式对羟基肉桂酸乙酯(19)、木犀草素(20)。结论化合物1~2、5~6、11~17、19为首次从荛花属中分离得到,1~2、4~6、11~19为首次从该植物中分离得到。
AIM To study the chemical constituents from Wikstroemia chamaedaphne Meisn.METHODS The 70% ethanol extract from W. chamaedaphne was isolated and purified by silica, Sephadex LH-20, recrystallization and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twenty compounds were isolated and identified as piperitol(1),forsythialan A(2),eudesmin(3),seamamin(4),torilin(5),3,4-divanillyltetrahydrofuran(6), syringaresinol(7), lariciresinol(8), pinoresinol(9), pinoresinol-4-O-β-D-glucopyrano side(10), eriodictyol(11), eriodictyol-7,3-dimethyl-ether(12), caffeic acid ethyl ester(13),methyl caffeate(14), blumenol B(15),5,7-dihydroxychromone(16),5-hydroxy-7-methoxychromone(17), naringenin(18),p-hydroxyl ethyl cinnamate(19) and luteolin(20).CONCLUSION Compounds 1-2,5-6,11-17,19 are isolated from genus wikstroemia for the first time. Compounds 1-2,4-6,11-19 are isolated from this plant for the first time.
作者
牛峥
陈玲玲
贺文达
麦燕随
卜子君
刘育坛
陈建南
黄松
NIU Zheng;CHEN Ling-ling;HE Wen-da;MAI Yan-sui;BU Zi-jun;LIU Yu-tan;CHEN Jian-nan;HUANG Song(Dongguan Institute for Mathematics and Theoretics Engineering Research of Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;Kunming Dendrobium Dream Pharmaceutical Co., Ltd., Kunming 652200, China)
出处
《中成药》
CAS
CSCD
北大核心
2019年第7期1586-1591,共6页
Chinese Traditional Patent Medicine
基金
教育厅-国家级重大培育项目(自然科学类)基金(2014GKXM032)
广东省重大科技专项基金(2013A022100002)
关键词
河朔荛花
化学成分
分离鉴定
Wikstroemia chamaedaphne Meisn
chemical constituents
isolation and identification
