摘要
目的观察温针灸配合自拟中药汤剂治疗活动性类风湿关节炎(RA)的疗效及对患者外周血CRP、IL-1、IL-6及TNF-α的影响。方法将128例活动性RA患者随机分为治疗组和对照组,每组64例。两组均给予双氯芬酸纳胶囊治疗,对照组在此基础上给予自拟中药汤剂治疗,治疗组给予温针灸配合自拟中药汤剂治疗。观察两组患者治疗前后外周血CRP、IL-1、IL-6及TNF-α的变化情况,并比较两组临床疗效。结果治疗组总有效率为93.8%,对照组为84.4%,两组比较差异具有统计学意义(P<0.05)。治疗组与对照组治疗期间不良反应发生率分别为14.1%和12.5%,两组比较差异无统计学意义(P>0.05)。两组治疗后关节疼痛数及血清CRP、IL-1、IL-6及TNF-α与同组治疗前比较,差异均具有统计学意义(P<0.05)。治疗组治疗后关节疼痛数及血清CRP、IL-1、IL-6及TNF-α与对照组比较,差异具有统计学意义(P<0.05)。结论温针灸配合自拟中药汤剂和双氯芬酸纳胶囊是一种治疗活动性RA的有效方法,能改善患者的临床关节功能障碍,降低外周血CRP、IL-1、IL-6及TNF-α含量。
Objective To investigate the clinical efficacy of warm needling moxibustion plus self-made decoction in treating active rheumatoid arthritis(RA)and the effect of C-reactive protein(CRP),interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)contents in peripheral blood.Method One hundred and twenty-eight patients with active RA were randomized to treatment and control groups,with 64 cases in each group.Both groups took diclofenac capsules orally.The treatment group received warm needling moxibustion plus taking self-made decoction additionally and the control group took self-made decoction alone.The CRP,IL-1,IL-6 and TNF-αcontents in peripheral blood in the two group were observed,and the clinical efficacies of the two groups were compared.Result The total efficacy rate was 93.8%in the treatment group and 84.4%in the control group,and there was a statistically significant difference between the two groups(P<0.05).The incidence of adverse reactions rate was 14.1%in the treatment group and 12.5%in the control group,and there was no statistically significant difference between the two groups(P>0.05).The number of joint pain and the serum CRP,IL-1,IL-6 and TNF-αcontents showed a significant change after the treatment in the two groups(P<0.05).After the treatment,the number of joint pain and the serum CRP,IL-1,IL-6 and TNF-αcontents in the treatment group were significantly different from those in the control group(P<0.05).Conclusion Warm needling moxibustion plus self-made decoction and diclofenac capsules orally is an effective approach in treating active RA.It can improve the clinical joint dysfunction in patients and down-regulate the CRP,IL-1,IL-6 and TNF-αcontents in peripheral blood.
作者
王福育
万家兴
张晨耀
朴洋
丁雪辉
李俊峰
WANG Fu-yu;WAN Jia-xing;ZHANG Chen-yao;PU Yang;DING Xuehui;LI Junfeng(Guang’anmen Hospital,China Academy of Chinese Medicine Science,Beijing 102618,China;The Frist center Hospital of Tianjin,Tianjin 300192,China)
出处
《上海针灸杂志》
2019年第7期779-783,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
天津卫生和计划生育委员会中医和中西医结合科研课题(2015048)
关键词
针灸疗法
温针疗法
关节炎
类风湿
白介素-1
白介素-6
C-反应蛋白
肿瘤坏死因子-α
Acupuncture and moxibustion therapy
Needle warming therapy
Arthritis,Rheumatoid
Interleukin-1
Interleukin-6
C-reactive protein
Tumor necrosis factor-α
