摘要
目的研究红花黄色素在治疗急性脑卒中患者的效果以及对凝血-纤溶系统和血清纤维蛋白原(FIB)水平的影响。方法急性脑卒中患者158例,按随机数字法分为观察组与对照组,每组79例;对照组给予血压控制、血糖控制及抗凝等基础治疗,观察组在对照组的基础上加注红花黄色素,2组持续治疗15d。观察2组患者治疗15d后临床有效率;采用的衡量标准为美国国立卫生研究院卒中量表(NIHSS评分)以及神经内科MRS评分表评价患者的残障程度,并测定患者血清凝血-纤溶系统相关指标、FIB水平、血清抗氧化指标及血管内皮功能指标;记录2组不良反应发生率情况。结果治疗15d后,观察组的有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者的NIHSS和MRS评分下降幅度均明显大于对照组(P<0.05);2组的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)含量均无明显变化(P>0.05),但观察组纤溶酶原活性(PLG)上升幅度明显大于对照组(P<0.05);2组FIB水平比较,差异无统计学意义(P>0.05),但观察组超氧化物歧化酶(SOD)及一氧化氮(NO)含量上升、丙二醛(MDA)含量下降幅度均大于对照组(P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用红花黄色素治疗急性脑卒中疗效显著,能明显降低患者的残障程度,提高PLG水平,且对凝血时间和血清FIB水平无影响。
Objective To investigate the therapeutic effects of carthamin yellow on acute stroke and its influence on coagulation-fibrinolysis system and serum fibrinogen(FIB) levels of patients.Methods A total of 158 patients with acute stroke who were admitted and treated in our hospital from March 2016 to March 2018 were divided into observation group(n=79) and control group(n=79) according to the random number table method.The patients in control group were treated by basic treatment of blood pressure control,blood glucose control and anti-coagulation,however,the patients in observation group,on the basis of control group,were treated by carthamin yellow,with a treatment course of 15 days for both groups.The clinical effective rate,the disability degree of patients evaluated according to the National Institutes of Health Stroke Scale(NIHSS score) and Neurology MRS score,and the related indexes of serum coagulation-fibrinolysis system,fibrinogen(FIB) levels,serum antioxidant indexes and vascular endothelial function indexes as well as the incidence rate of adverse reactions were observed and compared between the two groups.Results After 15-day treatment,the effective rate in observation group was significantly higher than that in control group(97.47% vs 83.54%,P<0.05).After 15-day treatment,the decrease degree of NIHSS scores and MRS scores in observation group was significantly greater than that in control group(P<0.05).However there were no significant differences in the activated partial thromboplastin time(APTT) and prothrombin time(PT) between the two groups(P > 0.05),but the increase degree of plasminogen activities(PLG) in observation group was significantly greater than that in control group(P<0.05).In addition there were no significant differences in FIB levels between the two groups(P > 0.05),but the increase degree of superoxide dismutase(SOD) and nitric oxide(NO) and the decrease degree of malondialdehyde(MDA) in observation group were significantly greater than those in control group(P<0.05).Moreover there was no significant difference in the incidence rate of adverse reactions between the two groups(P > 0.05).Conclusion The therapeutic effects of carthamin yellow on acute stroke are significant,which can significantly reduce the disability degree and increase the PLG levels of patients,moreover,which has no effects on coagulation time and serum FIB levels.
作者
毛士明
曹金强
汪万国
MAO Shiming;CAO Jinqiang;WANG Wanguo(Department of Neurology,People’s Hospital of Zhijiang City,Hubei,Zhijiang 443200,China)
出处
《河北医药》
CAS
2019年第14期2157-2160,共4页
Hebei Medical Journal
关键词
急性脑卒中
红花黄色素
疗效
凝血
纤溶
acute cerebral stroke
carthamin yellow
therapeutic effects
blood coagulation
fibrinolysis
