摘要
目的探讨肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)基因位点rs1800629单核苷酸多态性与宫颈癌发生的关系。方法选择经组织学确诊的汉族552例新发宫颈癌患者作为病例组,与病例组人群不存在生物学相关的654例正常人群作为对照组,利用Taqman实时荧光定量聚合酶链式反应(polymerase chain reaction,PCR)技术检测基因型,Logistic回归模型计算基因型与人群罹患宫颈癌的风险比(odds ratio,OR)及其95%的可信区间(95%CI);Stata 11. 0软件对中国人群rs1800629多态性与宫颈癌的关系进行Meta分析。结果与TNF-αrs1800629野生型GG基因型的相比,个体携带rs1800629 GA、AA及GA/AA基因型的个体罹患宫颈癌的风险差异无统计学意义(均有P> 0. 05);对该位点多态性与宫颈癌关系的Meta分析发现,TNF-αrs1800629遗传变异与中国人群宫颈癌的发生无明显相关性。结论 TNF-α基因rs1800629位点多态性可能与中国人群宫颈癌发生无关。
Objective To investigate the relationship between tumor necrosis factor α( TNF-αrs1800629 polymorphisms and cervical cancer risk. Methods A case-control study was carried out including 552 patients with cervical cancer and 654 normal controls during the same period. TNF-αrs1800629 polymorphisms were examined by Taqman-Probe assay method. The association between the genotypes and cervical cancer was analyzed by Logistic regression models. Stata 11. 0 was used for the Meta-analysis. Results Compared with the TNF-α rs1800629 GG genotype,individuals with GA,AA and GA/AA genotypes showed no significant changes in the risk of cervical cancer( all P > 0. 05). Further Meta-analysis on the relationship between the polymorphisms of TNF-α rs1800629 and cervical cancer also suggested that there was no significant correlation between the genetic variation and the occurrence of cervical cancer. Conclusion The polymorphisms of TNF-α rs1800629 may not be related to cervical cancer risk in Chinese population.
作者
丁波
孙玮
沈杨
蔡云朗
王适之
DING Bo;SUN Wei;SHEN Yang;CAI Yun-lang;WANG Shi-zhi(Department of Obstetrics and Gynecoloty,Affiliated Zhongda Hospital of Southeast University,Nanjing 210009,China;Department of Gynecology and Obstetrics,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210036,China;School of public health,Southeast university,Nanjing 210009,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2019年第7期850-855,共6页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81872684)
江苏省自然科学基金(BK20171367)~~
