摘要
目的:探讨多巴胺联合地塞米松对重症肺炎患儿血清细胞因子水平的影响。方法:选取2016年5月-2018年5月本院收治的重症肺炎患儿96例。按照随机数字表法将其分为研究组和对照组,各48例。对照组应用地塞米松治疗,研究组在对照组基础上应用多巴胺治疗,比较两组疗效、不良反应、症状消失时间、炎性因子(IL-6、IL-8、TNF-α、CRP)水平。结果:研究组总有效率为95.8%,高于对照组的83.3%(P<0.05);研究组退热时间、肺啰音消失时间、咳嗽消失时间均短于对照组(P<0.05);治疗后,研究组IL-6、IL-8、TNF-α、CRP均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在针对重症肺炎患儿的治疗过程中,采用多巴胺联合地塞米松治疗可有效降低患儿体内炎症反应程度,改善临床症状,促进患儿康复,且具有较高的安全性,临床上应当进一步推广应用。
Objective:To investigate the effect of Dopamine combined with Dexamethasone on serum cytokine levels in children with severe pneumonia.Method:A total of 96 children with severe pneumonia admitted to our hospital from May 2016 to May 2018 were selected.According to the random number table method,they were divided into study group and control group,48 cases in each group.The control group was treated with Dexamethasone,study group was treated with Dopamine on the basis of control group.The efficacy,adverse reactions,disappearance time of symptoms,inflammatory factors(IL-6,IL-8,TNF-α,CRP)levels between two groups were compared.Result:The total effective rate was 95.8%in study group,which was higher than 83.3%of control group(P<0.05).The time of fever abatement,lung rale disappearance and cough disappearance in study group were shorter than those of control group(P<0.05).After treatment,the levels of IL-6,IL-8,TNF-αand CRP in study group were lower than those of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In the treatment of children with severe pneumonia,the combination of Dopamine and Dexamethasone can effectively reduce the degree of inflammation in children,improve clinical symptoms,and promote the rehabilitation of children with high safety,which should be further promoted and applied in clinic.
作者
崔红艳
CUI Hongyan(Jiamusi Central Hospital,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2019年第20期67-70,共4页
Medical Innovation of China
