摘要
目的:评价苄星青霉素与头孢曲松联用对老年隐性梅毒感染的疗效及其对T细胞免疫功能的影响。方法:选取2016年1月—2017年1月间收治的老年隐性梅毒感染患者60例资料,按治疗方法的不同将其随机分组为对照组和联用组,每组30例;对照组患者给予苄星青霉素治疗,联用组患者则在对照组基础上加用头孢曲松治疗,比较两组患者治疗前后的外周血T淋巴细胞(CD3、CD4、CD8、CD4/CD8)水平测得值的变化情况,以及治疗后随访24月不同时间段的梅毒滴度(RPR)转阴率和总有效率的差异。结果:治疗后两组患者血清CD3、CD4、CD4/CD8水平测得值均高于治疗前(P<0.05),CD8水平值则低于治疗前(P<0.05);联用组患者治疗后血清CD3、CD4、CD4/CD8水平高于对照组(P<0.05),CD8水平低于对照组(P<0.05);治疗后24月的RPR转阴率高于治疗后6月、12月(P<0.05);联用组患者治疗不同时段的RPR转阴率均高于对照组(P<0.05),总有效率高于对照组(P<0.05)。结论:采用苄星青霉素与头孢曲松联合治疗老年隐性梅毒感染患者的疗效较为确切,有效改善了外周血T淋巴细胞水平,且提高了RPR转阴率。
Objective: To evaluate the efficacy of benzathine penicillin combined with ceftriaxone on elderly patients with recessive syphilis and its influence on T cell immunologic function. Methods: The data of 60 cases of elderly patients with latent syphilis infection admitted from January 2016 to January 2017 were selected. According to different treatment methods, they were randomly divided into control group and combination group, with 30 cases in each group. The control group was treated with benzathine penicillin, while the combined group was treated with ceftriaxone on TOP of the control group. The changes of T lymphocyte(CD3, CD4, CD8 and CD4/CD8) levels in peripheral blood before and after treatment were compared between the two groups, and the differences of syphilis drop degree of rapid plasma reactivity test for syphilis(RPR) conversion rate and total effective rate in different time periods after 24 months of follow-up were also compared. Results: After treatment, serum CD3, CD4 and CD4/CD8 levels in the two groups were all higher than those before treatment(P<0.05), while CD8 levels were lower than those before treatment(P<0.05). After treatment, serum levels of CD3, CD4 and CD4/CD8 in the combined treatment group were higher than those in the control group(P<0.05), and CD8 levels were lower than those in the control group(P<0.05). The negative conversion rate of RPR 24 months after treatment was higher than that of 6 months and 12 months after treatment(P<0.05). The RPR negative conversion rate of patients in the combined treatment group was higher than that of the control group(P<0.05), and the total effective rate was higher than that of the control group(P<0.05). Conclusion: The combination of benzathine penicillin and ceftriaxone in the treatment of elderly patients with recessive syphilis has should a relatively definite efficacy, effectively improving the level of peripheral blood T lymphocytes, as well as improving the rate of RPR negative transformation.
作者
叶文峰
YE Wen-feng(Department of Infectious Diseases, Ganzhou People's Hospital, Ganzhou Jiangxi 341000, China)
出处
《抗感染药学》
2019年第6期943-946,共4页
Anti-infection Pharmacy
基金
赣州市科技计划项目(编号:GZ2015zsf221)
关键词
隐性梅毒感染
苄星青霉素
头孢曲松
梅毒滴度
recessive syphilis
benzathine penicillin
ceftriaxone
syphilis drop degree
