摘要
随着现代社会的不断发展,高龄不孕女性的数量逐渐增加,这些患者最终往往需要辅助生殖技术(assisted reproductive technology,ART)的帮助。然而随着女性年龄的增长,卵子数量及质量均存在不同程度的下降,如何帮助这些高龄患者尽早怀孕是辅助生殖领域一直在探讨的问题。本文对高龄女性的生理改变特点,主要为下丘脑-垂体-卵巢(hypothalamus-pituitary-ovary,HPO)轴的改变特点,包括高龄女性卵巢储备功能的改变与卵巢反应性评估方法、神经内分泌变化特征进行了一些探讨;同时对目前可用的控制性超促排卵(controlled ovarian hyperstimulation,COH)方案进行一些简单的总结和特点归纳,希望可以为每个高龄不孕女性患者寻求更好的个性化助孕策略提供参考。
With the continuous development of modern society, the number of elderly women with infertility is gradually increasing, and these patients often need the help of assisted reproductive technology (ART). However, with the increase of women’s age, the number and the quality of eggs declines significantly. How to help these women to get pregnant as early as possible is an important issue in the field of assisted reproduction. In this article, the following topics will be discussed: 1) the characteristics of the physiological changes of elderly women about hypothalamus-pituitary-ovary (HPO) axis, including the changes in their ovarian reserve and neuroendocrine systems;2) the summary and comparison of currently available controlled ovarian hyperstimulation (COH) protocols. It is hoped that every elderly women get optimal personalized treatment.
作者
全心馨
匡延平
芦雪峰
Quan Xinxin;Kuang Yanping;Lu Xuefeng(Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2019年第6期457-461,共5页
Chinese Journal of Reproduction and Contraception
关键词
高龄
不孕症
助孕策略
下丘脑-垂体-卵巢轴
卵巢储备功能
控制性超促排卵
Advanced age
Infertility
Strategy of treatment
Hypothalamus-pituitary-ovary axis
Ovarian reserve
Controlled ovarian hyperstimulation
