摘要
目的使用不同抗病毒药物治疗慢性乙型肝炎患者血清HBV-DNA载量变化及应答情况,为该地区乙肝治疗方案提供数据指导。方法选取2016年1月—2017年12月在新疆巴州人民医院就诊的CHB患者167例,分为5组抗病毒药物治疗,检测患者血清基线水平和接受核苷酸类似物治疗12、24、48、72、96 周时HBV-DNA、HBeAg、ALT的变化情况。结果5组药物分别治疗12周HBV-DNA转阴率差异无统计学意义(χ^2=2.348,P=0.672),而接受治疗24、48、72、96周HBV-DNA转阴率之间差异有统计学意义(χ^2=11.086,P=0.026;χ^2=10.942,P=0.017;χ^2=10.738,P=0.030;χ^2=30.788,P=0.000)。48周后,5组HBeAg转阴率、ALT复常率差异无统计学意义(χ^2=7.232,P=0.124;χ^2=7.830,P=0.098);HBV-DNA转阴率差异有统计学意义(χ^2=10.942,P=0.017)。治疗96周,TDF组和ETV组可获得完全病毒学应答。结论检测血清HBV-DNA载量变化对抗病毒疗效的判断优于HBeAg、ALT;该地区TDF和ETV抗病毒效果良好,可获得完全病毒学应答,值得推广。
Objective To treat the changes of serum HBV-DNA load and response in patients with chronic hepatitis B by using different antiviral drugs, and provide data guidance for hepatitis B treatment in the region. Methods A total of 167 patients with CHB who were admitted to the People's Hospital of Bazhou, Xinjiang from January 2016 to December 2017 were enrolled in the study. The patients were divided into 5 groups of antiviral drugs, and the serum baseline levels and nucleotide analogues were measured. Changes in HBV-DNA, HBeAg, and ALT at 12, 24, 48, 72, and 96 weeks. Results There was no statistically significant difference in the rate of HBV-DNA conversion between the 5 groups of drugs treated for 12 weeks (χ^2=2.348, P=0.672), and the difference between HBV-DNA negative rate at 24, 48, 72, and 96 weeks after treatment. Were statistically significant (χ^2=11.086, P=0.026;χ^2=10.942, P=0.017;χ^2=10.738, P=0.030;χ^2=30.788, P=0.000). After 48 weeks, there was no statistically significant difference in the rate of HBeAg conversion and ALT recurrence between the 5 groups (χ^2=7.232, P=0.124;χ^2=7.830, P=0.098);the difference of HBV-DNA conversion rate was statistically significant (χ^2=10.942, P=0.017). After 96 weeks of treatment, a complete virological response was obtained in the TDF and ETV groups. Conclusion The detection of serum HBV-DNA load is better than HBeAg and ALT in the treatment of antiviral efficacy. The antiviral effect of TDF and ETV in this region is good, and a complete virological response can be obtained, which is worthy of promotion.
作者
韩霞
施丽
王路
沈黎俊
HAN Xia;SHI Li;WANG Lu;SHEN Li-jun(Department of Medical Laboratory,Bazhou People's Hospital of Xinjiang,Bazhou,Xinjiang,841000 China;Department of Infectious Diseases,Bazhou People's Hospital,Bazhou,Xinjiang,841000 China)
出处
《世界复合医学》
2019年第8期7-9,共3页
World Journal of Complex Medicine
基金
自治州科学技术研究（“星火”）项目
巴州地区乙肝患者荧光定量PCR检测结果与乙肝疗效的分析（201717）
