摘要
目的评价逍遥散合生脉饮加减结合西医常规疗法治疗干眼症的疗效。方法将符合入选标准的76例干眼症患者按随机数字表法分为2组,每组38例。对照组给予西医常规疗法治疗,观察组在对照组基础上结合逍遥散合生脉饮加减治疗。2组均治疗4周。分别于治疗前后进行自觉症状评分,并依据角膜荧光素染色试验(fluorescent test, FL)、泪膜破裂时间(breakup time of tear film, BUT)、基础泪液分泌试验(schirmer I test, SIT)评价泪膜稳定性;采用ELISA法检测泪液中IL-1b、IL-6及TNF-a含量,评价临床疗效。结果观察组总有效率为92.9%(65/70)、对照组为76.4%(55/72),2组比较差异有统计学意义(Z=-2.991,P=0.002)。治疗后,观察组SIT[(6.9±0.8)mm比(4.3±0.5)mm,t=3.751]、BUT[(10.5±1.6)s比(6.4±0.8)s,t=4.228]均高于对照组(P<0.05),FL[(0.9±0.1)分比(1.4±0.2)分,t=3.208]评分均低于对照组(P<0.05);观察组干涩、异物感、视疲劳、畏光及视物模糊评分均低于对照组(t值分别为3.559、4.015、4.119、3.983、4.120,P值均<0.05);泪液中IL-1b、IL-6及TNF-a水平均低于对照组(t值分别为11.887、8.028、8.112,P值均<0.001)。结论逍遥散合生脉饮加减结合西医常规疗法可提高干眼症患者的泪膜稳定性,减轻眼表局部炎症反应,改善临床症状,提高临床疗效。
Objective To evaluate the effect of Xiaoyaosan and Shengmaiyin combined with conventional western medicine for xerophthalmia. Methods A total of 76 xerophthalmia patients who met the criteria were divided into two groups according to random number table, with 38 cases in each group. The control group was treated with routine western medicine, while the observation group was treated with Xiaoyaosan combined with Shengmaiyin on the basis of the control group. Both groups were treated for 4 weeks. Before and after treatment, the symptoms were scored, and the tear film stability was evaluated according to the results of fluorescent test (FL), breakup time of tear film (BUT) and schirmer I test (SIT). The contents of IL-1β, IL-6 and TNF-α in tear were detected by ELISA, and the clinical efficacy was evaluated. Results The total effective rate was 92.9%(65/70) in the observation group and 76.4%(55/72) in the control group, and there was significant difference between the two groups (Z=-2.991, P=0.002). After treatment, the SIT (6.9 ± 0.8 mm vs. 4.3 ± 0.5 mm, t=3.751), BUT (10.5 ± 1.6 s vs. 6.4 ± 0.8 s, t=4.228) in the observation group were significantly higher than those in the control group (P<0.05). The FL score (0.9 ± 0.1 vs. 1.4 ± 0.2, t=3.208) in the observation group was significantly lower than that of the control group (P<0.05). The scores of aningeresting, foreign body sensation, visual fatigue, photophobia and visual blur in the observation group were significantly lower than those in the control group (t were 3.559, 4.015, 4.119, 3.983, 4.120, all Ps<0.05). The levels of IL-1β, IL-6 and TNF-α in tear were significantly lower than those in control group (t were 11.887, 8.028, 8.112, all Ps<0.001). Conclusions The Xiaoyaosan combined with Shengmaiyin can improve tear film stability, relieve local ocular surface inflammation and improve clinical symptoms in patients with xerophthalmia.
作者
王鸿雁
王霞
尹春红
刘力苇
刘国权
Wang Hongyan;Wang Xia;Yin Chunhong;Liu Liwei;Liu Guoquan(Department of Ophthalmology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China)
出处
《国际中医中药杂志》
2019年第8期825-828,共4页
International Journal of Traditional Chinese Medicine
关键词
干眼病
逍遥散
生脉散
泪器疾病
视力试验
炎症反应
中西医结合疗法
Xerophthalmia
Xiao Yao San
Sheng Mai San
Lacrimal apparatus diseases
Vision tests
Inflammatory reaction
Integrated Chinese traditional and western medicine therapy
