摘要
目的:探讨地诺前列酮栓与缩宫素注射液引产对中晚期妊娠患者阴道流血、月经复潮时间及宫内妊娠物残留率的影响。方法:选取2016年4月至2018年4月上海交通大学医学院附属苏州九龙医院收治的中晚期妊娠患者250例,采用随机数字表法分为A组和B组,每组125例。A组患者采用地诺前列酮栓促宫颈成熟药引产,B组患者采用缩宫素注射液引产。观察两组患者促宫颈成熟效果、引产效果、分娩情况与产后结局及新生儿情况。结果:给药后6、12 h,两组患者宫颈Bishop评分较给药前明显升高,且A组患者明显高于B组,差异均有统计学意义(P<0.05)。A组患者的引产总有效率为89.60%(112/125),明显高于B组的79.20%(99/125),差异有统计学意义(P<0.05)。A组患者阴道流血时间、用药至临产时间及总产程明显短于B组,阴道分娩率明显高于B组,差异均有统计学意义(P<0.05);A组患者产后24 h出血量、宫内妊娠物残留率明显低于B组,月经复潮时间明显短于B组,差异均有统计学意义(P<0.05);两组患者产褥感染率、宫颈裂伤率的差异均无统计学意义(P>0.05)。A组新生儿Apgar评分明显高于B组,而胎儿窘迫率、新生儿窒息率明显低于B组,差异均有统计学意义(P<0.05)。结论:与缩宫素注射液相比,采用地诺前列酮栓促宫颈成熟药引产可缩短中晚期妊娠患者阴道流血时间、月经复潮时间,在提高引产成功率的同时改善母婴结局。
OBJECTIVE: To probe into the effects of dinoprostone suppository and oxytocin injection on vaginal bleeding, menstrual recovery time and intrauterine pregnancy residual rate in patients with middle and advanced pregnancy. METHODS: Totally 250 patients with middle and advanced pregnancy admitted into Suzhou Jiulong Hospital, Shanghai Jiaotong University School of Medicine from Apr. 2016 to Apr. 2018 were extracted to be divided into the group A and the group B via the random number table, with 125 cases in each group. Patients in group A were induced by dinoprostone, while the group B was induced by oxytocin injection. Results of cervical maturation, induction of labor, delivery, postpartum outcome and neonatal conditions of two groups were observed. RESULTS: After administration of 6 and 12 h, Bishop score of cervix in both groups increased significantly compared with before administration, and the group A was significantly higher than the group B, with statistically significant differences(P<0.05). The total effective rate of labor induction in group A was 89.60%(112/125), significantly higher than that in group B [79.20%(99/125)], and the difference was statistically significant(P<0.05). The vaginal bleeding time, medication to labor time and total labor duration in group A were significantly shorter than those in group B, and the rate of vaginal delivery was significantly higher than that in group B, with statistically significant differences(P<0.05). The bleeding volume and residual rate of intrauterine gestational tissues in group A were significantly lower than those in group B, and the menstrual recovery time was significantly shorter than that in group B, with statistically significant differences(P<0.05). There was no significant difference in the rate of puerperal infection and cervical laceration between two groups(P>0.05). Apgar score of neonates in group A was significantly higher than that of group B, while the rate of fetal distress and neonatal asphyxia were significantly lower than that of group B, with statistically significant differences(P<0.05). CONCLUSIONS: Compared with oxytocin injection, the use of dinoprostone can shorten the vaginal bleeding time and menstrual recovery time in patients with middle and advanced pregnancy, increase the success rate of induction of labor and improve the maternal and infant outcomes.
作者
王杰
尤子善
蒋立
WANG Jie;YOU Zishan;JIANG Li(Dept. of Obstetrics, Suzhou Jiulong Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Jiangsu Suzhou 215000, China)
出处
《中国医院用药评价与分析》
2019年第8期956-958,960,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药物引产
中晚期妊娠
阴道流血时间
月经复潮时间
宫内妊娠物残留率
Drug induced labor
Middle and advanced pregnancy
Vaginal bleeding time
Menstruation recovery time
Residual rate of intrauterine gestational tissues
