摘要
本文报告用噬菌体诱导试验对20种抗肿瘤药物的致突变性进行筛选,并用Ames试验、SOS固体显色试验和噬菌体诱导试验3种方法联合测试其中11种药物的致突变性,各种试验方法均做加和不加大鼠肝脏微粒体酶代谢活化系统(S9)的两种试验。结果15种药物有致突变作用,阳性率为75％。三种试验方法联合检测的符合率为72.73％。
This paper investigated the mutagenic effects induced by 20 antineoplastic chemical drugs with the SOS inductest, SOS chromotest and Ames assay. The results indicated that 15 of the 20 (75%) chemical drugs could induce mutations in the test strains, no matter S9 (rat liver microsomal enzymes) were present or not. The three tests yielded an agreement rate of 72. 73%.
出处
《癌变．畸变．突变》
CAS
CSCD
1992年第5期42-44,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
抗癌药
致突变
antineoplastic drugs
mutagenicity
Ames assay
SOS chromotest
SOS inductest
