摘要
使用胶银染色技术对88例胃良、恶性病变及正常胃粘膜进行核仁组成区定量研究。结果表明:慢性胃溃疡之修复性增生上皮及癌旁粘膜平均每核含AgNOR量及AgNOR异形率均高于正常胃粘膜上皮(P<0.05),慢性胃溃疡增生上皮及癌旁粘膜上皮两者之间无明显差异。高分化腺癌与正常胃粘膜上皮、慢性胃溃疡修复上皮及癌旁粘膜上皮相比,平均每核含AgNOR量、AgNOR异形率及AgNOR颗粒在核内的大小及位置分布等均差异非常显著(P<0.01),提示AgNOR定量研究对区分胃良、恶性上皮有重要参考价值。
By the use of silver colloid staining technique nucleolar organizer region associated proteins (AgNOR) have been studied quantitatively in paraffin section of 88 benign, malignant lesions and normal gastric muco.sa. The results showed that the mean number and irregularity of AgNORs per nucleus in iepairing epithelium of chronic gastric ulcer and mucosa adjacent to carcinoma was, found to be higher than that of normal mucosa epitheliu n (P<0.05). There was no significant difference between proliferating epithelium of chrc c gastric ulcer and mucosa adjacent to carcinoma. There were significant differences between well differentiated cancer, normal mucosa, mucosa adjacent to carcinoma and repairing epithelium of chronic gcastric ulcer in number, irregularity of AgNORs and distribution of number, size and location (P<0.01). It was suggested that quantitative study on AgNOR may have important referent value in differentiation of benign and malignant epithelium of stomach.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1992年第4期273-275,共3页
Chinese Journal of Cancer
基金
广东省自然科学基金
关键词
核仁组成区
组织化学
胃肿瘤
诊断
Gastric carcinoma Gastric epitheilum AgNOR DNA RNA histochemistry Quantitative method
