摘要
目的 :研究食管鳞状细胞癌中细胞周期素D1 (cyclinD1 )、钙粘附蛋白 (E cadherin ,E cad)、连接蛋白 (cat)α、β、γ的表达及临床病理学意义。方法 :采用免疫组织化学法检测 62例食管癌手术标本的cyclinD1、E cad、α cat、β cat、γ cat蛋白表达 ,并结合临床随访资料进行分析。结果 :cyclinD1、E cad、α cat、β cat、γ cat阳性病例分别为 35例 (56 5 % )、39例 (62 9% )、49例(79% )、59例 (95 2 % )和 47例 (75 8% )。其中α cat与 β cat、E cad蛋白表达呈正相关性 ,其相关系数分别为 0 2 74和 0 2 79(P <0 0 5)。γ cat蛋白缺失表达与淋巴结转移有显著相关性 (P <0 0 5) ;E cad、γ cat蛋白缺失与保留表达和肿瘤分化程度、术后生存期长短 ,在统计学上有差异 (P <0 0 5)。结论 :E cad、γ cat缺失表达是食管癌预后差的因素之一。
Purpose To investigate the expression of cyclinD1, E cadherin,α catenin,β catenin and γ catenin and its clinicopathology in esophageal cancer. Methods CyclinD1,E cadherin,α catenin,β catenin and γ catenin expression were examined immunohistochemically in 62 cases of esophageal cancer and the clinical data were analyzed. Result The expression rates of cyclinD1, E cadherin,α catenin,β catenin and γ catenin were 56 5%, 62 9%, 79%, 95 2% and 75 8% respectively. The loss expression was of γ catenin was related to lymph nodes metastasis of tumors( P< 0 05). The expression of E cadherin and γ catenin was related to the degree of tumor differentiation and survive time. α catenin expression was correlated positively with β catenin and E cadherin. Conclusion The loss expression of E cadherin and γ catenin is correlated to poor prognosis in esophageal cancer which may serve as a parameter for determining tumor biological behavior and prognosis. The expression of α catenin and cyclinD1 is not related to histological grades and invasion depth and lymph nodes metastasis.
出处
《临床与实验病理学杂志》
CAS
CSCD
2002年第5期493-495,共3页
Chinese Journal of Clinical and Experimental Pathology
基金
汕头大学研究与发展基金项目资助 (NoL0 30 0 2 )汕头大学研究与发展基金项目资助 (NoL0 30 0 2 )
