摘要
目的 :探讨交叉表达淋系和髓系相关抗原的急性白血病患者的生物学与临床特征及预后。方法 :用流式细胞术检测白血病细胞的免疫表型 ,根据FAB亚型和免疫标记将病例分为 6组 :CD7表达阳性的急性髓细胞性白血病 (CD7+ AML)、CD7表达阴性的伴淋系相关抗原的急性髓细胞性白血病 (CD7-Ly+ AML)、不伴淋系相关抗原的急性髓细胞性白血病 (Ly-AML)、伴髓系相关抗原的急性淋巴细胞性白血病 (My+ ALL)、不伴髓系相关抗原的急性淋巴细胞性白血病 (My-ALL)和急性杂合性白血病 (HAL)。结果 :CD7+ AML组的白细胞数高于Ly-AML组及CD7-Ly+ AML组 ,诱导缓解率 (16 .7% )低于Ly-AML组 (71.4 % ) ,有显著差异 ;CD7-Ly+ AML组与Ly-AML组的临床特征无显著性差异。My+ ALL组与My-ALL组的临床特征无显著性差异。HAL组与My+ALL组和Ly+ AML组分别比较 ,发病年龄较高 ,白细胞数较高 ,贫血较明显 ,平均缓解期及平均生存期较短。结论 :CD7+ AML较之Ly-AML及CD7-Ly+ AML具有不同的临床特征 ,预后较差 ,可以看作一个独特的临床亚型。HAL与My+ ALL和Ly+ AML相比较 ,具有不同的临床特征 ,应该区别对待。
Objective:To investigate the biological and clinical characteristics and prognosis of actue leukemia of cross expressing lymphoid and myeloid lineage associated antigens.Method:Using flow cytometry to examine the immunophenotype of leukemic cells. All patients are classified into six groups according to FAB subtypes and immunophenotypes: acute myeloid leukemia displaying lymphoid surface marker CD 7(CD 7 +AML),acute myeloid leukemia displaying lymphoid surface markers without CD 7 expression(CD 7 -Ly +AML), acute lymphoblastic leukemia displaying myeloid surface markers (My +ALL), acute lymphoblastic leukemia displaying no myeloid surface markers(My -ALL) and hybrid acute leukemia(HAL). Result:The white blood cell(WBC) count of CD 7 +AML patients is higher than Ly -AML and CD 7 -Ly +AML patients; the complete remission rate of CD 7 +AML patients is lower than Ly -AML patients; the clinical characteristics of CD 7 -Ly +AML patients and Ly -AML patients have no significant difference. There was no significant differences in clinical features between My +ALL patients and My -ALL patients. HAL patients are differ from My +ALL or Ly +AML on the following aspects: the median age is relatively high, the WBC count is relatively high, anemia is comparatively apparent, the median remission duration and the median surival are relatively short.Conclusion:CD 7 +AML are differ from Ly -AML and CD 7 +AML on clinical characteristics, it may present a particular subset of AML.HAL have different clinical features from Ly +AML and My +ALL, it should be treated differently.
出处
《临床血液学杂志》
CAS
2002年第6期258-260,共3页
Journal of Clinical Hematology
关键词
急性白血病
交叉表达
淋系相关抗原
髓系相关抗原
血液肿瘤
免疫表型
Cross expressing
Myeloid lineage associated antigen
Lymphoid lineage associated antigen
Acute leukemia
Immunophenotype
