摘要
目的探讨中药口服联合穴位注射治疗神经根型颈椎病的临床疗效及对炎症因子的影响。方法采用随机抽签法将130例神经根型颈椎病患者分为对照组和试验组各65例。2组均予牵引治疗,试验组在此基础上并予中药口服联合穴位注射,每日1次。2组均治疗5 d后休息2 d,连续治疗4周。比较2组临床疗效,观察2组治疗前后中医症状评分、McGill疼痛问卷(MPQ)评分、颈椎病临床评价量表(CASCS)评分、相关肌肉表面肌电信号中位频率及炎症因子水平。结果试验组总有效率为95.38%(62/65),对照组为73.85%(48/65),试验组近期疗效明显优于对照组(P<0.05)。与本组治疗前比较,2组治疗后中医症状评分、MPQ评分明显降低,CASCS评分明显升高(P<0.05);2组治疗后比较,试验组上述评分明显优于对照组(P<0.05)。与本组治疗前比较,试验组治疗后相关肌肉表面肌电信号中位频率明显提高(P<0.05);2组治疗后比较,试验组相关肌肉表面肌电信号中位频率明显高于对照组(P<0.05)。与本组治疗前比较,试验组治疗后白细胞介素(IL)-1β、肿瘤坏死因子-α及IL-6水平明显降低(P<0.05);2组治疗后比较,试验组上述炎症因子水平明显低于对照组(P<0.05)。结论中药口服联合穴位注射治疗神经根型颈椎病可有效减轻患者症状体征,缓解疼痛,提高生活自理能力,并能改善相关肌肉表面肌电信号中位频率,降低炎症因子水平。
Objective To investigate the clinical efficacy of TCM combined with acupoint injection in the treatment of patients with cervical spondylotic radiculopathy and its effetcs on inflammatory cytokines.Methods Totally 130 patients with cervical spondylotic radiculopathy were divided into control group and experiment group through random lottery method,with 65 cases in each group.Both groups were treated with traction,and the experiment group was given TCM combined with acupoint injection,once a day.Both groups were treated for 5 days and rested for 2 days for 4 weeks.The clinical efficacy of the two groups was compared.The TCM symptom scores,McGill pain questionnaire(MPQ)score,cervical spondylosis clinical evaluation scale(CASCS)score,relevant muscle surface EMG signal median frequency and cytokine levels of the two groups were observed before and after treatment.Results The total effective rate of the experiment group was 95.38%(62/65),and that of the control group was 73.85% (48/65). The short-term efficacy of the experiment group was significantly better than that of thecontrol group (P<0.05). Compared with before treatment, the TCM symptom scores and MPQ scores of the twogroups significantly decreased, and the CASCS scores significantly increased (P<0.05). After treatment, the abovescores of the experiment group were significantly better than the control group (P<0.05). Compared with beforetreatment, the median frequency of muscle surface EMG signal in the experiment group significantly increased aftertreatment (P<0.05);After treatment, the median frequency of muscle surface EMG signal of the experiment group wassignificantly higher than that of the control group (P<0.05). Compared with before treatment, the levels of interleukin(IL)-1β, tumor necrosis factor-α and IL-6 significantly decreased in the experiment group (P<0.05);After treatment,the cytokine levels in the experiment group were significantly lower than those in the control group (P<0.05).Conclusion TCM combined with acupoint injection in the treatment of patients with cervical spondyloticradiculopathy can efficiently alleviate symptoms and signs, relieve pain, improve self-care ability, improve the medianfrequency of muscle surface EMG signal and reduce the expression of cytokines.
作者
丁晓燕
陈建秋
刘薛峰
谢磊
李明礼
余思云
DING Xiaoyan;CHEN Jianqiu;LIU Xuefeng;XIE Lei;LI Mingli;YU Siyun(Jiading District Hospital of Traditional Chinese Medicine of Shanghai City,Shanghai 201800,China;Gongli Hospital of Shanghai Pudong New District,Shanghai 200135,China;Affiliated Municipal Hospital of Traditional Chinese Medicine to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;First Rehabilitation Hospital of Shanghai City,Shanghai 200090,China;Shanghai Jiading District Maternal and Child Health Hospital,Shanghai 201800,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2019年第9期38-42,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金(81603485)
关键词
穴位注射
神经根型颈椎病
炎症因子
临床研究
acupoint injection
cervical spondylotic radiculopathy
cytokine
clinical efficacy
