摘要
μ阿片受体激动剂临床应用悠久广泛,多年来作为镇痛的主要药物,因其副作用多而影响镇痛效果。纳布啡(Nal)是大部κ阿片受体激动剂和小部分μ阿片受体拮抗剂,该文探求Nal在骨科手术麻醉中的临床应用和研究,以及将来可能的发展方向。综述Nal药学特性、动物实验、小儿及成人患者关于骨科手术麻醉方面的用药情况,证实其镇痛可靠且副作用少、安全性高;预测Nal可用于多种用药方式的镇痛。
Mu opioid receptor agonists have been widely used in clinic for a long time,which have been the main analgesic drugs for many years,with more side effects affecting the analgesic effect.Nalbuphine is a major kappa opioid receptor agonists and a minor mu opioid receptor antagonists.To seek the clinical application and research of nalbuphine in orthopedic surgery anesthesia and the possible future directions,this paper has reviewed the pharmacological characteristics of nalbuphine,animal experiment,the use of drugs in pediatric and adult orthopedic surgery anesthesia.It has been proved that nalbuphine has reliable analgesic effect,fewer side effects and high safety.It will be predicted that nalbuphine can be used in various ways of analgesia and the dosage or mode of administration of nalbuphine need to be further studied.
作者
时利荣
陈志强
王静
李荣
Li-rong Shi;Zhi-qiang Chen;Jing Wang;Rong Li(Department of Anesthesiology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia 014010,China)
出处
《中国现代医学杂志》
CAS
2019年第20期43-48,共6页
China Journal of Modern Medicine
