摘要
目的:考察榄香烯注射液与常见4种溶媒配伍后其输液稳定性及活性成分含量变化的情况,为临床药物治疗选择合理溶媒配伍提供参考。方法:将榄香烯注射液分别与5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液、5%葡萄糖氯化钠注射液配伍,室温下放置6h,然后观察溶液颜色与外观、pH值,以及使用HPLC测定β-榄香烯活性成分变化情况。结果:榄香烯注射液与4种溶媒配伍后6h内颜色外观、pH值和含量无明显变化。结论:榄香烯注射液与4种常见输液溶媒配伍6h内稳定。
Objective:To explore the stability and active ingredient in elemene injection after its compatibility with 4 transfusions,and to provide reference for clinical drug treatment to choose reasonable solvent compatibility.Methods:The content ofβ-elemene was determined by HPLC,pH values were determined by pH meter,and the color of solution and change of appearance were observed 6 hours after conpatility with 4 transfusions(5%glucose injection,10%glucose injection,0.9%sodium chloride injection and 5%glucose sodium chloride injection).Results:There was no significant difference in color appearance,pH value and content ofβ-elemene injection after the mixing with 4 varieties of infusions in 6 hours.Conclusion:Elemene injection is stable after dissolved in the 4 solvents in 6 hours.
作者
宁萍
饶晓黎
胡玉
NING Ping;RAO Xiaoli;HU Yu(Cardiothoracic Surgery,the First People’s Hospital of Chuzhou City,Anhui Province 239000)
出处
《医学理论与实践》
2019年第19期3041-3042,3064,共3页
The Journal of Medical Theory and Practice
