摘要
目的探析应用前列地尔联合丁二磺酸腺苷蛋氨酸对严重肝损害患者进行治疗的临床效果。方法方便选取2013年3月—2018年11月该院收治的72例存在严重肝损害的患者,根据其就诊时间先后平均分为参照组与治疗组,各有36例。参照组给予常规综合治疗,治疗组患者在常规治疗基础上采用前列地尔联合丁二磺酸腺苷蛋氨酸治疗。观察对比两组患者治疗前后的肝功能、临床疗效、死亡率及不良反应。结果治疗后,治疗组患者的血清总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平均明显低于参照组,差异有统计学意义(t=2.210、3.890、4.460,P<0.05);治疗组的总有效率(80.56%%)明显高于参照组(52.78%),治疗组患者死亡率(13.89%)则低于参照组(38.89%),差异有统计学意义(χ^2=6.250、5.790,P<0.05);参照组患者无明显不良反应,治疗组出现3例(8.33%)不良反应,两组差异无统计学意义(χ^2=3.130,P>0.05)。结论对严重肝损害患者应用前列地尔与丁二磺酸腺苷蛋氨酸进行联合治疗可促进患者肝功能的改善,提升治疗效果,提高患者存活率,值得推广应用。
Objective To investigate the clinical effect of alprostadil combined with adenosine succinate on patients with severe liver damage.Methods 72 patients with severe liver damage admitted to the hospital from March 2013 to November 2018 were convenient selected and randomly divided into a reference group and a treatment group according to their time of treatment,36 cases each.The reference group was given conventional comprehensive treatment,and the patients in the treatment group were treated with alprostadil in combination with adenosine succinate.Liver function,clinical efficacy,mortality and adverse reactions were compared between the two groups before and after treatment.Results After treatment,the serum total bilirubin(TBiL),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)levels in the treatment group were significantly lower than the reference group,and the difference was statistically significant(t=2.210,3.890,4.460,P<0.05);the total effective rate of the treatment group(80.56%)was significantly higher than that of the reference group(52.78%),and the mortality rate of the treatment group(13.89%)was lower than that of the reference group(38.89%),the difference was statistically significant(χ^2=6.250,5.790,P<0.05);there was no statistically significant adverse reaction in the reference group,and 3 cases(8.33%)had adverse reactions in the treatment group.There was no significant difference between the two groups(χ^2=3.130,P>0.05).Conclusion The combination of alprostadil and adenosine succinate in patients with severe liver damage can improve the liver function of patients,improve the therapeutic effect and improve the survival rate of patients.It is worthy of popularization and application.
作者
薛建平
XUE Jian-ping(Department of Gastroenterology,Tongshan District People's Hospital,Xuzhou,Jiangsu Province,221000 China)
出处
《中外医疗》
2019年第28期49-51,共3页
China & Foreign Medical Treatment
关键词
前列地尔
丁二磺酸腺苷蛋氨酸
严重肝损害
Alprostadil
Adenosine monophosphate methionine
Severe liver damage
