NGAL在肠道炎症中作用的研究进展被引量：4

Research progress on role of NGAL in intestinal inflammation

在线阅读下载PDF

导出

摘要中性粒细胞明胶酶相关载脂蛋白(NGAL)是lipocalin家族成员之一,在不同的病理生理状态下,能与相应配体结合,表现出复杂的生物功能,在肠道黏膜免疫、调节肠道微生物及消化道肿瘤的发生等方面有一定作用。本文就NGAL的作用机制、分子调控及其在肠道炎症和肿瘤中的作用做一综述。 Neutrophil gelatinase-associated lipocalin(NGAL)is a member of the lipocalin family,which can bind to the corresponding ligands under different pathophysiological conditions and exhibit complex biological functions.It plays a certain role in intestinal mucosal immunity,regulation of intestinal microbes and the occurrence of digestive tract tumors.This article reviewed the mechanism,molecular regulation of NGAL and its role in intestinal inflammation and tumors.

作者刘文仝巧云 LIU Wen;TONG Qiaoyun(First Clinical Medical College of Three Gorges University,Yichang,Hubei 443000,China)

机构地区三峡大学第一临床医学院

出处《重庆医学》 CAS 2019年第21期3735-3738,共4页 Chongqing medicine

关键词中性粒细胞明胶酶相关载脂蛋白基质金属蛋白酶9 铁微生物炎症性肠病肠肿瘤 neutrophil gelatinase-associated lipocalin matrix metalloproteinase 9 Fe microorganism inflammatory bowel disease intestinal neoplasms

分类号 R574.62 [医药卫生—消化系统]

引文网络
相关文献

参考文献2

1Aito Ueno,Abhisek Ghosh,Daniel Hung,Ji Li,Humberto Jijon.Th17 plasticity and its changes associated with inflammatory bowel disease[J].World Journal of Gastroenterology,2015,21(43):12283-12295. 被引量：24
2刘海燕.中性粒细胞明胶酶相关载脂蛋白通路关键因子在溃疡性结肠炎患者体内变化的研究[J].中国临床药理学杂志,2017,33(23):2371-2374. 被引量：3

二级参考文献24

1Pierre Desreumaux,Arnaud Foussat,Matthieu Allez,Laurent Beaugerie,Xavier Hébuterne,Yoram Bouhnik,Maria Nachury,Valérie Brun,Hervé Bastian,Nathalie Belmonte,Michel Ticchioni,Agnès Duchange,Patricia Morel–Mandrino,Virginie Neveu,Nathalie Clerget–Chossat,Miguel Forte,Jean–Frédéric Colombel.Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn’s Disease[J].Gastroenterology.2012(5)
2Josefowicz Steven Z,Lu Li-Fan,Rudensky Alexander Y.Regulatory T cells: mechanisms of differentiation and function. Annual Review of Immunology . 2012
3Hou‐Pu Liu,Anthony T. Cao,Ting Feng,Qingjie Li,Wenbo Zhang,Suxia Yao,Sara M. Dann,Charles O. Elson,Yingzi Cong.TGF‐β converts Th1 cells into Th17 cells through stimulation of Runx1 expression[J]. Eur. J. Immunol. . 2015 (4)
4Bart‐Jan Kroesen,Nato Teteloshvili,Katarzyna Smigielska‐Czepiel,Elisabeth Brouwer,Anne Mieke H. Boots,Anke Berg,Joost Kluiver.SJWD14120900000298[J]. Immunology . 2015 (1)
5Jonathan A. Rebhahn,Nan Deng,Gaurav Sharma,Alexandra M. Livingstone,Sui Huang,Tim R. Mosmann.An animated landscape representation of CD4<sup>+</sup> T‐cell differentiation, variability, and plasticity: Insights into the behavior of populations versus cells[J]. Eur. J. Immunol. . 2014 (8)
6Magdalena Huber,Michael Lohoff.IRF4 at the crossroads of effector T‐cell fate decision[J]. Eur. J. Immunol. . 2014 (7)
7Nagendra Singh,Ashish Gurav,Sathish Sivaprakasam,Evan Brady,Ravi Padia,Huidong Shi,Muthusamy Thangaraju,Puttur D. Prasad,Santhakumar Manicassamy,David H. Munn,Jeffrey R. Lee,Stefan Offermanns,Vadivel Ganapathy.Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis[J]. Immunity . 2014 (1)
8Yoshiyuki Goto,Casandra Panea,Gaku Nakato,Anna Cebula,Carolyn Lee,Marta Galan Diez,Terri M. Laufer,Leszek Ignatowicz,Ivaylo I. Ivanov.Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation[J]. Immunity . 2014 (4)
9John J. O’Shea,Yuka Kanno,Andrew C. Chan.In Search of Magic Bullets: The Golden Age of Immunotherapeutics[J]. Cell . 2014 (1)
10Caroline Raffin,Pascale Pignon,Clotilde Celse,Emilie Debien,Danila Valmori,Maha Ayyoub.Human Memory Helios? FOXP3+ Regulatory T Cells (Tregs) Encompass Induced Tregs That Express Aiolos and Respond to IL-1β by Downregulating Their Suppressor Functions[J]. The Journal of Immunology . 2013 (9)