摘要
目的预测逍遥散潜在的主要活性成分和作用靶点,探索其多成分-多靶点-多通路治疗抑郁症的可能作用机制。方法采用中医药整合药理学研究平台构建逍遥散抗抑郁成分靶标-疾病靶标网络,通过网络分析方法筛选关键节点,并在此基础上对关键节点进行通路富集分析,探索逍遥散治疗抑郁症可能参与的生物过程。结果逍遥散中多个成分可通过钠钾ATP酶α1,及ATP合酶α,β和γ亚基等靶点,调节三羧酸循环、糖代谢、氨基酸代谢、5-羟色胺能突触和氧化磷酸化等通路发挥抗抑郁作用。结论逍遥散可能通过“多成分-多靶点”模式调节能量代谢发挥抗抑郁作用。
OBJECTIVE To predict the action targets of antidepressant active ingredients of Xiaoyaosan in order to find out more about the"multi-component,multi-target and multi-pathway"mechanism.METHODS The target-disease target network of Xiaoyaosan antidepressant was constructed by using the integrative pharmacology-based research platform of traditional Chinese medicine.The key nodes were screened by network analysis method,and the pathway enrichment analysis of the key nodes was carried out on the basis of the network analysis method to explore its possible biological process in the treatment of depression.RESULTS Many components of Xiaoyaosan had antidepressant prop erties through ATPase Na^+/K^+transporting subunit alpha 1,ATP synthase subunit alpha,beta and gamma targets,involving tricarboxylic acid cycle,carbohydrate metabolism,amino acid metabolism,serotonergic synapse and oxidative phosphorylation pathways.CONCLUSION Xiaoyaosan plays an antidepressant role in regulating the energy metabolism through"the multi-component and multi-target"model.
作者
高耀
许腾
吴丹
田俊生
秦雪梅
GAO Yao;XU Teng;WU Dan;TIAN Jun-sheng;QIN Xue-mei(Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM,Taiyuan 030006,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2019年第7期481-491,共11页
Chinese Journal of Pharmacology and Toxicology
基金
国家科技重大专项(2017ZX09301047)
山西省科技重点研发计划(201603D3113013)
山西省自然科学基金(201701D121137)
山西省重点实验室资助项目(201605D111004)
山西省科技创新重点团队资助项目(201605D131045-18)
山西省研究生教育创新项目(2016SY007)
山西省研究生教育创新项目(2017JD02)~~
关键词
逍遥散
整合药理学
抑郁症
能量代谢
作用机制
Xiaoyaosan
integrative pharmacology
depression
energy metabolism
mechanism
