摘要
目的探讨气管支气管腺样囊性癌的临床特点、诊治及预后,提高对本病的认识。方法回顾性分析11例气管支气管腺样囊性癌患者的临床资料。结果11例气管支气管腺样囊性癌患者中,男5例,女6例;年龄21~69岁;中央型10例,周围型1例。主要症状包括咳嗽、咳痰、气短、呼吸困难、咯血。行手术治疗7例,化疗5例,放疗3例,气管镜下介入治疗4例。随访结果显示,10例获得随访,占91%,1 a生存率100%、3 a生存率90%、5 a生存率80%。结论气管支气管腺样囊性癌临床少见,发病年龄跨度大,症状主要是中央气道阻塞表现,手术治疗效果佳,放疗有效,个别化疗有效,但易复发,气管镜下介入治疗对减轻症状疗效确切,有待尝试靶向治疗等新的治疗手段。
Objective To study the clinical characteristics,diagnosis and treatment,prognosis of tracheal adenoidcystic carcinoma,and to improve the understanding.Methods The clinical data of 11 patients with tracheal adenoidcystic carcinoma were retrospectively analyzed.Results Of the 11 patients,5 patients were male,6 patients were female.The age was 21 to 69 years old.The tumors of 10 patients located in the central airway,1 patient located in the lungs.Main symptoms included cough,sputum,dyspnea,shortness of breath,hemoptysis.Seven patients received surgical treatment,5 patient chemotherapy,3 patients radiotherapy,4 patients interventional treatment under the bronchoscope.Ten patients(91%)got the follow-up.The 1-year survival rate was 100%,the 3-year survival rate was 90%,the 5-year survival rate was 80%.Conclusion Tracheal adenoidcystic carcinoma is rare,the onset age span is great,symptoms are caused mainly by the obstruction of central airway.The effect of operation treatment is good,radiotherapy is effective,chemotherapy is effectivefor individual patients,but it is easy to relapse,interventional therapy under bronchoscope is effective to relieve symptoms,can significantly prolong survival time.The new treatment such as targeted therapy should be used.
作者
刘待见
高崴崴
LIU Daijian;GAO Weiwei(Department of Respiratory Medicine,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)
出处
《肿瘤基础与临床》
2019年第4期319-322,共4页
journal of basic and clinical oncology
关键词
气管支气管腺样囊性癌
临床特点
治疗
预后
tracheal adenoidcystic carcinoma
clinical characteristics
treatment
prognosis
