摘要
目的探究同步放化疗对中晚期食管癌患者免疫功能的影响。方法选取2014年1月至2018年12月期间我院收治的60例中晚期食管癌患者,按治疗方案的区别分为实验组和对照组,每组各30例。对照组采用放射治疗联合对症支持治疗的方法,实验组则采取同步放化疗进行治疗。通过对两组患者治疗前及治疗后6个月的血清免疫球蛋白A(IgA)、免疫球蛋白M(IgM)及免疫球蛋白G(IgG)的水平变化情况进行统计分析,从而探究其免疫功能的恢复情况。结果治疗前,两组患者各项血清免疫球蛋白的水平差异无统计学意义(P>0.05);治疗后,实验组患者血清免疫球蛋白A(IgA)、免疫球蛋白M(IgM)及免疫球蛋白G(IgG)的水平均明显高于同期对照组患者的相应指标,且组间及组内差异均具有统计学意义(P<0.05)。结论同步放化疗可有效恢复中晚期食管癌患者的免疫功能,从而提高临床治疗效果,因此可尝试将该治疗方式应用于中晚期食管癌患者的治疗当中。
Objective To investigate the effect of concurrent chemoradiotherapy on immune function in patients with advanced esophageal cancer.Methods Sixty patients with advanced esophageal cancer admitted to our hospital from January 2014 to December 2018 were enrolled.The patients were divided into experimental group and control group according to the difference of treatment options,with 30 cases in each group.The control group was treated with radiotherapy combined with symptomatic supportive therapy,while the experimental group was treated with concurrent chemoradiotherapy.Through the statistical analysis of the changes of serum immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)levels before and after treatment in the two groups of patients,the immune system was explored.The recovery of the function.Results Before treatment,there was no significant difference in serum immunoglobulin levels between the two groups(P>0.05).After treatment,serum immunoglobulin A(IgA)and immunoglobulin M(IgM)were used in the experimental group.The level of immunoglobulin G(IgG)was significantly higher than that of the control group,and the difference between the groups and the group was statistically significant(P<0.05).Conclusion Synchronous chemoradiotherapy can effectively restore the immune function of patients with advanced esophageal cancer,thus improving the clinical treatment effect.Therefore,this treatment can be applied to the treatment of patients with advanced esophageal cancer.
作者
邰璐
刘永新
TAI Lu;LIU Yong-xin(Department of Oncology,82nd Hospital of the Chinese People’s Liberation Army,Huaian,Jiangsu 223001)
出处
《智慧健康》
2019年第29期104-105,124,共3页
Smart Healthcare
关键词
同步放化疗
中晚期食管癌
免疫功能
影响
Concurrent chemoradiotherapy
Advanced esophageal cancer
Immune function
Influence
