摘要
目的比较强迫障碍患者脑灰质体积与健康对照的差异,并分析患者脑灰质体积有改变脑区与认知功能和临床症状的关系。方法选取首发强迫障碍患者36例和年龄、性别、受教育程度相匹配的健康对照35名,进行头部磁共振扫描,采用基于体素的形态学分析测量受试者大脑灰质体积,患者组使用神经认知成套测验和耶鲁-布朗强迫症状量表(Yale-Brown obsessive-compulsive scale,Y-BOCS)评估认知功能和强迫症状。结果与对照组相比,患者组脑灰质体积增加的脑区有额顶叶(左侧中央后回、左侧中央前回)(t=4.299,P<0.0005,体素>100)、颞叶-边缘系统(左侧梭状回、左侧颞上回、左侧颞中回、左侧海马旁回)(t=4.841,P<0.0005,体素>100);脑灰质体积减少的脑区为双侧前扣带回(t=-4.181,P<0.0005,体素>100)。患者组中,颞叶-边缘系统的灰质体积与社会认知评分正相关(r=0.347,P=0.038),前扣带回的灰质体积与强迫思维评分正相关(r=0.416,P=0.012)。结论强迫障碍患者在额顶叶、颞叶-边缘系统、双侧前扣带回等广泛的脑区存在灰质体积改变,其中颞叶-边缘系统灰质体积与社会认知、前扣带回灰质体积与强迫思维存在关联。
Objective To investigate the characteristics of gray matter volume in Obsessive Compulsive Disorder(OCD) patients compared with healthy controls, and to explore the correlation between brain regions with altered gray matter volume and the patients’ cognitive function and clinical symptoms. Method Thirty-six patients with first-episode OCD and 35 healthy controls who were matched by age, gender and education level were selected and examined by MATRICS Consensus Cognitive Battery(MCCB) and Yale-Brown Obsessive Compulsive Scale(Y-BOCS). The head MRI and the Voxel-based morphometry was used to test the volume of gray matter. The correlation analysis was conducted to analyze the correlation between brain areas with altered gray matter volume and patients’ cognitive function and Y-BOCS results. Results Compared with the control group, the OCD group had increased gray matter volume in frontal parietal lobe(postcentral gyrus-L, precentral gyrus-L)(t =4.299, P <0.0005, voxels >100) and temporal-limbic system(fusiform gyrus-L, superior temporal gyrus-L, medial temporal lobe-L, parahippocampal gyrus-L)(t =4.841, P <0.0005, voxels >100). Meanwhile, the volume of gray matter decreased in bilateral anterior cingulate gyrus(t=-4.181, P<0.0005, voxels>100). In the case group, there were a positive correlation between the volume of gray matter in the temporal lobo-limbic system and social cognition score(r=0.347,P=0.038) and a positive correlation between the volume of gray matter in the anterior cingulate gyrus and obsessions score(r =0.416,P =0.012). Conclusion Patients with OCD have abnormal gray matter volume in a wide range of brain regions, including the frontal parietal lobe, the temporal-limbic system, and bilateral anterior cingulate gyrus, among which the volume of gray matter in the temporal-limbic system is correlated with social cognition, and gray matter volume in the anterior cingulate gyrus is correlated with obsessions.
作者
牛琪惠
贾得焕
牛明敏
程敬亮
刘俊宏
杨磊
李幼辉
NIU Qihui;JIA Dehuan;NIU Mingmin;CHENG Jingliang;LIU Junhong;YANG Lei;LI Youhui(Department of Psychiatry,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2019年第10期595-601,共7页
Chinese Journal of Nervous and Mental Diseases
基金
河南省科技重大攻关项目(编号：142102310512)
西部精神医学协会科研基金(编号：Wcpafund-201608)
关键词
强迫障碍
磁共振成像
基于体素的形态学分析
脑灰质体积
认知功能
Obsessive-compulsive disorder
Magnetic resonance imaging
Voxel-based morphometry
Gray matter volume
Cognitive function
