摘要
目的了解陕西省健康人群戊型肝炎病毒(Hepatitis E virus,HEV)血清流行率。方法采用分层随机抽样方法于2013年5-6月抽取陕西省3个县0-65岁健康人群,检测血清抗-HEV IgG抗体,分析抗体阳性率。结果陕西省0-65岁健康人群抗-HEV IgG阳性率为15.82%(218/1378,标化阳性率:26.59%),男、女性分别为13.78%、17.82%(χ^2=4.21,P=0.040),<1岁、1-4岁、5-14岁、15-65岁分别为14.63%、11.22%、5.79%、30.13%(χ^2=92.46,P<0.001),3个县分别为汉阴县14.23%、泾阳县22.33%、洛川县11.35%(χ^2=20.75,P<0.001)。结论陕西省健康人群HEV感染率相对较高,存在显著的地区、年龄差异;建议对高危人群接种戊肝疫苗。
Objective To determine the sero-prevalence of hepatitis E virus(HEV)antibody in Shaanxi province.Methods We used a stratified random sampling method to select healthy people,aged 0-65 years,from three counties of Shaanxi in May-June 2013.We tested serum samples for anti-HEV IgG antibody,and determined the HEV antibody positivity rate.Results The positivity rate of anti-HEV IgG was 15.82%(218/1378,adjusted rate:26.59%)among 0-65 year old healthy people in Shaanxi.Positivity rates were 13.78%for males and 17.82% for females(χ^2=4.21,P=0.040),and were 14.63%,11.22%,5.79%,and 30.13%(χ^2=92.46,P<0.001)for<1,1-4,5-14,and 15-65 year olds,respectively.Antibody positivity rates were 14.23%,22.33%,and 11.35%(χ^2=20.75,P<0.001)for Hanyin,Jingyang,and Luochuan counties.Conclusion Based on anti-HEV IgG antibody positivity rates,the HEV infection rate was relatively high among healthy people in Shaanxi,and varied with region and age.We recommend hepatitis E vaccine for high-risk groups.
作者
胡伟军
刘晓宇
司源
张少白
Hu Weijun;Liu Xiaoyu;Si Yuan;Zhang Shaobai(Shaanxi Provincial Center for Disease Control and Prevention,Xi'an 710054,Shaanxi,China)
出处
《中国疫苗和免疫》
北大核心
2019年第5期521-523,531,共4页
Chinese Journal of Vaccines and Immunization
